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Non-invasive Intradermal Delivery of Hyaluronic Acid via Iontophoresis
https://tokushima-u.repo.nii.ac.jp/records/2011297
https://tokushima-u.repo.nii.ac.jp/records/2011297f6544b14-83bb-4bd9-ad6c-aed71f0a1f1a
| 名前 / ファイル | ライセンス | アクション |
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bpb_46_11_1635.pdf (2.23 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2024-01-11 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1248/bpb.b23-00408 | |||||||||||||||||||||||
| 関連名称 | 10.1248/bpb.b23-00408 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Non-invasive Intradermal Delivery of Hyaluronic Acid via Iontophoresis | |||||||||||||||||||||||
| 著者 |
イノウエ, シンヤ
× イノウエ, シンヤ
× オオシマ, ヤスフミ
× 小暮, 健太朗
WEKO
1139
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| 内容記述 | Hyaluronic acid (HA) is a hydrophilic supra-macromolecule, with a molecular weight (MW) 1000000<. HA is recognized as a biomaterial for skin moisturization. HA solution is typically injected into the skin using a needle. However, needle injection is invasive and does not result in homogeneous distribution of HA over a large area of skin. Therefore, non-invasive and effective technologies for homogenous intradermal delivery of HA are needed. Recently, we demonstrated the use of iontophoresis (ItP) for non-invasive intradermal delivery of various macromolecules, such as small interfering RNA (siRNA) (MW: 12000) and antibodies (MW: 150000). Based on our previous studies, we hypothesized that HA can also be delivered non-invasively into the skin by ItP. In this study, we applied ItP to fluorescence-labeled HA (MW: 600000–1120000 and 1200000–1600000) on rat dorsal skin. Following treatment, fluorescence was observed to be widely distributed in the skin, demonstrating successful intradermal delivery of HA via ItP. In addition, the relative moisture content and elasticity of skin treated with ItP/HA was temporarily higher than that of control skin. This is the first report demonstrating successful non-invasive intradermal delivery of HA and improvement of skin conditions by high-molecular weight HA delivered by ItP. In conclusion, ItP would be a useful technology for non-invasive intradermal delivery of high-molecular weight HA for treatment of skin diseases and cosmetology applications. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | iontophoresis | |||||||||||||||||||||||
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| 主題 | hyaluronic acid | |||||||||||||||||||||||
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| 主題 | non-invasive intradermal delivery | |||||||||||||||||||||||
| 書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 46, 号 11, p. 1635-1638, 発行日 2023-11-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 13475215 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 09186158 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11696048 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||||||||||||||||||||
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| 識別子 | 402917 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
