| Item type |
文献 / Documents(1) |
| 公開日 |
2023-11-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.3390/cancers14215258 |
|
|
関連名称 |
10.3390/cancers14215258 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
The Association of Tumor Immune Microenvironment of the Primary Lesion with Time to Metastasis in Patients with Renal Cell Carcinoma : A Retrospective Analysis |
| 著者 |
フジタ, カズトシ
キムラ, ゴウ
ツヅキ, トヨノリ
カトウ, タイゴ
バンノ, エリ
カザマ, アキラ
ヤマシタ, リョウ
マツシタ, ユウト
イシイ, ダイスケ
布川, 朋也
ナカガワ, ユウキ
フクヤマ, タマキ
サノ, フミカズ
コンドウ, ユキヒロ
ウエムラ, ヒロツグ
|
| 抄録 |
|
|
内容記述 |
The association between the tumor immune microenvironment (TIME) of primary lesions and time to metastasis remains unknown. The aim of our retrospective study was to investigate the differences in the TIME of primary lesions based on time intervals to metastasis, mainly between the synchronous group (SG; metastasis within 3 months) and metachronous group (MG; metastasis after 3 months), and its association with clinicopathological parameters in patients with metastatic renal cell carcinoma (mRCC). SG showed more immunogenic feature of TIME (PD-L1 positivity, CD8+ TIL infiltration) and poor prognostic pathological features (WHO/ISUP grade 4, necrosis, lymphovascular invasion, infiltrative growth pattern, and sarcomatoid differentiation). In addition, we observed that the time to metastasis differed by TIME characteristics (PD-L1 status, immunophenotype), which were associated with the WHO/ISUP grade. The TIME of primary lesions could affect the time to metastasis. |
| 抄録 |
|
|
内容記述 |
Biological or immunological differences in primary lesions between synchronous and metachronous metastatic renal cell carcinoma (mRCC) have been reported. However, the association between the tumor immune microenvironment (TIME) of primary lesions and time to metastasis remains unknown. We investigated the differences in the TIME of primary lesions based on time intervals to metastasis, mainly between the synchronous group (SG; metastasis within 3 months) and metachronous group (MG; metastasis after 3 months), and its association with clinicopathological parameters in patients with mRCC. Overall, 568 patients treated first-line with vascular endothelial growth factor receptor inhibitors comprised the analysis population (SG: N = 307 [54.0%]; MG: N = 261 [46.0%]). SG had a higher proportion of patients with poor prognostic pathological feature tumors: WHO/ISUP grade 4, necrosis, lymphovascular invasion, infiltrative growth pattern, and sarcomatoid differentiation. Regarding the TIME, more immunogenic features were seen in SG than MG, with a higher PD-L1 positivity and a lower proportion of the desert phenotype. This is the first study to examine the differences in the TIME of primary lesions in patients with mRCC based on the time intervals to metastasis. The TIME of primary lesions could affect the time to metastasis. |
| キーワード |
|
|
主題 |
TIME (tumor immune microenvironment) |
| キーワード |
|
|
主題 |
synchronous |
| キーワード |
|
|
主題 |
metachronous |
| キーワード |
|
|
主題 |
mRCC (metastatic renal cell carcinoma) |
| キーワード |
|
|
主題 |
PD-L1 |
| キーワード |
|
|
主題 |
immunophenotype |
| 書誌情報 |
en : Cancers
巻 14,
号 21,
p. 5258,
発行日 2022-10-26
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20726694 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
399084 |
| 言語 |
|
|
言語 |
eng |
cancers_14_21_5258.pdf (2.38 MB)
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