| Item type |
文献 / Documents(1) |
| 公開日 |
2023-12-20 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1111/1759-7714.14736 |
|
|
関連名称 |
10.1111/1759-7714.14736 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Late-onset acute type 1 diabetes mellitus 7 months after discontinuation of pembrolizumab against lung cancer |
| 著者 |
イチハラ, セイヤ
國重, 道大
カドタ, ナオキ
オカノ, ヨシオ
マチダ, ヒサノリ
ハタケヤマ, ノブオ
ナルセ, ケイシ
篠原, 勉
タケウチ, エイジ
|
| 抄録 |
|
|
内容記述 |
Immune-related adverse events (irAEs) occur in rare cases, even after the completion of immune checkpoint inhibitor (ICI) therapy. We encountered a lung cancer patient diagnosed with acute-onset type 1 diabetes mellitus (DM) 7 months after the cessation of ICI. A 68-year old woman was referred to our hospital for chest abnormalities. She was diagnosed with lung adenocarcinoma cT4N2M1c, stage IVB. Immunostaining showed that the expression of programmed death ligand 1 in tumor cells was negative. A genetic analysis using the Oncomine Dx Target Test Multi-CDx System revealed that the primary tumor was positive for ERBB2. Combined immunotherapy with carboplatin, pemetrexed, and pembrolizumab was performed as first-line therapy, followed by maintenance therapy with pemetrexed plus pembrolizumab, which was successful. After the seventh course, maintenance therapy was stopped because only the primary tumor showed local enlargement. Local chest radiotherapy (66 Gy/33 Fr) was performed, and the patient was followed up. HbA1c was 4.9% 3 months after the completion of pembrolizumab, and dry mouth and polyuria occurred after 5 months. Seven months later, the patient developed diabetic ketoacidosis with a blood glucose of 348 mg/dL and an HbA1c of 11.3%. Antiglutamic acid decarboxylase antibodies were negative and urinary C-peptide was 9.3 μg/day. The patient was diagnosed with acute-onset type 1 diabetes and received insulin therapy. There has been no case report of type 1 diabetes diagnosed 7 months after the last administration of an ICI. These results indicate that irAE needs to be considered even after the cessation of ICI. |
| キーワード |
|
|
主題 |
acute-onset type 1 diabetes |
| キーワード |
|
|
主題 |
after discontinuation |
| キーワード |
|
|
主題 |
immune-related adverse events |
| キーワード |
|
|
主題 |
late-onset |
| キーワード |
|
|
主題 |
non-small-cell lung cancer |
| 書誌情報 |
en : Thoracic Cancer
巻 14,
号 1,
p. 81-84,
発行日 2022-11-21
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17597714 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17597706 |
| 出版者 |
|
|
出版者 |
China Lung Oncology Group |
| 出版者 |
|
|
出版者 |
John Wiley & Sons Australia |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
397284 |
| 言語 |
|
|
言語 |
eng |
tc_14_1_81.pdf (1.82 MB)
.png)
