| Item type |
文献 / Documents(1) |
| 公開日 |
2023-11-28 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1507/endocrj.EJ19-0180 |
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|
関連名称 |
10.1507/endocrj.EJ19-0180 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Predictive factors of posttransplant glucose intolerance in Japanese patients with type 1 diabetes after pancreas transplantation |
| タイトル別表記 |
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その他のタイトル |
Prediction of post-PTx glucose tolerance |
| 著者 |
タカヒ, ヤスミツ
ミヤシタ, カズユキ
タカハラ, ミツヨシ
カタカミ, ナオト
黒田, 暁生
マツオカ, タカアキ
松久, 宗英
イトウ, トシノリ
シモムラ, イイチロウ
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| 抄録 |
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内容記述 |
Pancreas transplantation (PTx) has been performed worldwide for patients with type 1 diabetes accompanied with end-stage renal disease or uncontrollable glycemic fluctuation. Nevertheless, risk factors of posttransplant glucose intolerance, which is responsible for progress of diabetic complications, remains unclear, especially in cases without pancreatic graft function loss. Therefore, this study was conducted to search for predictive factors of future glucose tolerance in PTx recipients without pancreatic graft function loss. Subjects were selected from among 41 Japanese patients with type 1 diabetes who received PTx between 2000 and 2016 in Osaka University Hospital, and 24 subjects free from rejections and thromboses were analyzed. Several examinations to evaluate insulin secretion and insulin sensitivity within 6 months after transplantation (initial examination) were performed. Glucose tolerance was evaluated by 120-minute post-load plasma glucose level during 75-g oral glucose tolerance tests (OGTT), referred to as PGOGTT120, at the initial examination and between 1 year and 2 years posttransplantation (maintenance period). The initial examination factors that were correlated with PGOGTT120 in the maintenance period were PGOGTT120 [r = 0.52 (p = 0.01)], insulinogenic index [r = –0.65 (p < 0.01)], and the ratio of incremental area under the curve of insulin to that of plasma glucose (iAUCR) calculated from data of OGTT [r = –0.65 (p < 0.01)]. Insulinogenic index [β = –0.28 (p = 0.02)] and iAUCR [β = –0.29 (p = 0.02)] were still significantly correlated with PGOGTT120 in the maintenance period after adjustment for PGOGTT120 at the initial examination. In conclusion, insulinogenic index and iAUCR from OGTT performed in the early posttransplantation period were predictive factors of future glucose intolerance. |
| キーワード |
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|
主題 |
Type 1 diabetes mellitus |
| キーワード |
|
|
主題 |
Pancreas transplantation |
| キーワード |
|
|
主題 |
Posttransplant glucose intolerance |
| キーワード |
|
|
主題 |
75-g oral glucose tolerance test |
| 書誌情報 |
en : Endocrine Journal
巻 66,
号 12,
p. 1101-1112,
発行日 2019
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13484540 |
| 出版者 |
|
|
出版者 |
The Japan Endocrine Society |
| EID |
|
|
識別子 |
360618 |
| 言語 |
|
|
言語 |
eng |
endocrj_66_12_1101.pdf (1.06 MB)
