| Item type |
文献 / Documents(1) |
| 公開日 |
2024-01-12 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1111/cts.13638 |
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関連名称 |
10.1111/cts.13638 |
| 出版タイプ |
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出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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|
タイトル |
Valproic acid treatment attenuates cisplatin-induced kidney injury by suppressing proximal tubular cell damage |
| タイトル別表記 |
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その他のタイトル |
バルプロ酸投与は近位尿細管障害を抑制することによりシスプラチン誘発腎障害を抑制する |
| タイトル別表記 |
|
|
その他のタイトル |
VALPROIC ACID PROTECTS KIDNEYS FROM CISPLATIN |
| 著者 |
吉岡, 俊彦
合田, 光寛
カンダ, マサヤ
イトバヤシ, サユリ
スギモト, ユウゴ
(井澤)石澤, 有紀
八木, 健太
相澤, 風花
ミヤタ, コウジ
新村, 貴博
濱野, 裕章
サクラダ, タクミ
座間味, 義人
石澤, 啓介
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| 抄録 |
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内容記述 |
Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods. Sodium valproic acid is a prophylactic drug candidate with a high potential for clinical application against cisplatin-induced kidney injury. Therefore, in this study, we aimed to elucidate the mechanism underlying the prophylactic effect of valproic acid on cisplatin-induced kidney injury in a mouse model and HK2 and PODO cells with cisplatin-induced toxicity. In the mouse model of cisplatin-induced kidney injury, various renal function parameters and tubular damage scores were worsened by cisplatin, but they were significantly improved upon combination with valproic acid. No difference was observed in cisplatin accumulation between the cisplatin-treated and valproic acid-treated groups in whole blood and the kidneys. The mRNA expression levels of proximal tubular damage markers, apoptosis markers, and inflammatory cytokines significantly increased in the cisplatin group 72 h after cisplatin administration but significantly decreased upon combination with valproic acid. In HK2 cells, a human proximal tubular cell line, the cisplatin-induced decrease in cell viability was significantly suppressed by co-treatment with valproic acid. Valproic acid may inhibit cisplatin-induced kidney injury by suppressing apoptosis, inflammatory responses, and glomerular damage throughout the kidneys by suppressing proximal tubular cell damage. However, prospective controlled trials need to evaluate these findings before their practical application. |
| キーワード |
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|
主題 |
cisplatin |
| キーワード |
|
|
主題 |
adverse drug reaction |
| キーワード |
|
|
主題 |
renal injury |
| キーワード |
|
|
主題 |
valproic acid |
| キーワード |
|
|
主題 |
proximal tubule cell |
| 書誌情報 |
en : Clinical and Translational Science
巻 16,
号 11,
p. 2369-2381,
発行日 2023-09-12
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
17528062 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12625737 |
| 出版者 |
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|
出版者 |
Wiley |
| 出版者 |
|
|
出版者 |
American Society for Clinical Pharmacology and Therapeutics |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Toshihiko Yoshiokaの学位論文として提出され，学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院医学研究科（医学専攻） |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| EID |
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識別子 |
407554 |
| 言語 |
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言語 |
eng |
| 報告番号 |
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|
学位授与番号 |
甲第3762号 |
| 学位記番号 |
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|
値 |
甲医第1587号 |
| 学位授与年月日 |
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学位授与年月日 |
2023-10-26 |
| 学位名 |
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|
学位名 |
博士（医学） |
| 学位授与機関 |
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|
学位授与機関名 |
徳島大学 |
k3762_abstract.pdf (116 KB)
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