| Item type |
文献 / Documents(1) |
| 公開日 |
2023-12-11 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.70.361 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.70.361 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Early Prediction of Radiotherapeutic Efficacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using 18F-FLT and 18F-FDG PET/CT |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Predicting Therapeutic Effects using PET/CT |
|
言語 |
en |
| 著者 |
大谷, 環樹
生島, 仁史
坂東, 良美
山下, 理子
クワハラ, ケンメイ
大塚, 秀樹
近藤, 和也
三好, 弘一
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
This study investigated the usefulness of [18F]-3’-deoxy-3’-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged post-irradiation compared with pre-irradiation. In FT821 tumours, uptake of both 18F-FLT and 18F-FDG uptake was substantially decreased post-irradiation compared with pre-irradiation. In both xenografts, tumour volumes in the irradiated groups were significantly decreased compared with those in the control group. 18F-FLT is expected to contribute to individual NSCLC therapy because it accurately evaluates the decrease in tumour activity that cannot be captured by 18F-FDG. 18F-FDG may be useful for evaluating surviving cells without being affected by the inflammatory reaction at an extremely early stage, approximately 1 week after irradiation. Combined use of 18F-FLT and 18F-FDG PET/CT imaging may increase the accurate prediction of radiotherapy efficacy, which may lead to improved patient outcomes and minimally invasive personalised therapy. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
18F-fluorodeoxyglucose |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
18F-fluorothymidine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
irradiation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inflammation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
non-small cell lung cancer |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 70,
号 3-4,
p. 361-368,
発行日 2023-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
|
言語 |
en |
| EID |
|
|
識別子 |
403775 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_70_3-4_361.pdf (657 KB)
