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The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC
https://tokushima-u.repo.nii.ac.jp/records/2011568
https://tokushima-u.repo.nii.ac.jp/records/2011568fd2ed4bf-8f16-4c19-9038-0f501c5d7911
| 名前 / ファイル | ライセンス | アクション |
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ijbs_18_10_4053.pdf (4.88 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||||
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| 公開日 | 2024-01-25 | |||||||||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.7150/ijbs.73009 | |||||||||||||||||||||||||||||||||
| 関連名称 | 10.7150/ijbs.73009 | |||||||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||
| タイトル | The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC | |||||||||||||||||||||||||||||||||
| 著者 |
Wang, Yixiu
× Wang, Yixiu
× Xie, Yuwei
× Dong, Bingzi
× Xue, Weijie
× Chen, Shuhai
× 島田, 光生
WEKO
1253
× Zou, Hao
× Feng, Yujie
× Ma, Kai
× Dong, Qian
× Cao, Jingyu
× Zhu, Chengzhan
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| 抄録 | ||||||||||||||||||||||||||||||||||
| 内容記述 | Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and identification of novel targets is necessary for its diagnosis and treatment. This study aimed to investigate the biological function and clinical significance of tweety homolog 3 (TTYH3) in HCC. TTYH3 overexpression promoted cell proliferation, migration, and invasion and inhibited HCCM3 and Hep3B cell apoptosis. TTYH3 promoted tumor formation and metastasis in vivo. TTYH3 upregulated calcium influx and intracellular chloride concentration, thereby promoting cellular migration and regulating epithelial-mesenchymal transition-related protein expression. The interaction between TTYH3 and MK5 was identified through co-immunoprecipitation assays and protein docking. TTYH3 promoted the expression of MK5, which then activated the GSK3β/β-catenin signaling pathway. MK5 knockdown attenuated the activation of GSK3β/β-catenin signaling by TTYH3. TTYH3 expression was regulated in a positive feedback manner. In clinical HCC samples, TTYH3 was upregulated in the HCC tissues compared to nontumor tissues. Furthermore, high TTYH3 expression was significantly correlated with poor patient survival. The CpG islands were hypomethylated in the promoter region of TTYH3 in HCC tissues. In conclusion, we identified TTYH3 regulates tumor development and progression via MK5/GSK3-β/β-catenin signaling in HCC and promotes itself expression in a positive feedback loop. | |||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||
| 主題 | Tweety homolog 3 | |||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||
| 主題 | hepatocellular carcinoma | |||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||
| 主題 | tumor metastasis | |||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||
| 主題 | epithelial-mesenchymal transition | |||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||
| 主題 | positive feedback | |||||||||||||||||||||||||||||||||
| 書誌情報 |
en : International Journal of Biological Sciences 巻 18, 号 10, p. 4053-4070, 発行日 2022-06-21 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||
| 収録物識別子 | 14492288 | |||||||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||||||
| 出版者 | Ivyspring International Publisher | |||||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||||
| 権利情報 | This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. | |||||||||||||||||||||||||||||||||
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| 識別子 | 396264 | |||||||||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||||||||
