| Item type |
文献 / Documents(1) |
| 公開日 |
2024-01-19 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.3390/ijms24044050 |
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関連名称 |
10.3390/ijms24044050 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice |
| 著者 |
カサイ, カイチ
イガラシ, ナオヤ
タダ, ユウキ
カニ, コウダイ
タカノ, シュン
ヤナギバシ, ツトム
ウスイ カワニシ, フミタケ
| ja |
ウスイ カワニシ, フミタケ
|
| ja-Kana |
ウスイ カワニシ, フミタケ
|
| en |
Usui-Kawanishi, Fumitake
|
Search repository
フジサカ, シホ
ワタナベ, シロウ
(市村)清水, 真祐子
タカツ, キヨシ
トベ, カズユキ
常山, 幸一
フルサワ, ユキヒロ
ナガイ, ヨシノリ
|
| 抄録 |
|
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内容記述 |
The potential roles of the gut microbiota in the pathogenesis of non-alcoholic fatty liver disease, including non-alcoholic steatohepatitis (NASH), have attracted increased interest. We have investigated the links between gut microbiota and NASH development in Tsumura-Suzuki non-obese mice fed a high-fat/cholesterol/cholate-based (iHFC) diet that exhibit advanced liver fibrosis using antibiotic treatments. The administration of vancomycin, which targets Gram-positive organisms, exacerbated the progression of liver damage, steatohepatitis, and fibrosis in iHFC-fed mice, but not in mice fed a normal diet. F4/80+-recruited macrophages were more abundant in the liver of vancomycin-treated iHFC-fed mice. The infiltration of CD11c+-recruited macrophages into the liver, forming hepatic crown-like structures, was enhanced by vancomycin treatment. The co-localization of this macrophage subset with collagen was greatly augmented in the liver of vancomycin-treated iHFC-fed mice. These changes were rarely seen with the administration of metronidazole, which targets anaerobic organisms, in iHFC-fed mice. Finally, the vancomycin treatment dramatically modulated the level and composition of bile acid in iHFC-fed mice. Thus, our data demonstrate that changes in inflammation and fibrosis in the liver by the iHFC diet can be modified by antibiotic-induced changes in gut microbiota and shed light on their roles in the pathogenesis of advanced liver fibrosis. |
| キーワード |
|
|
主題 |
antibiotic |
| キーワード |
|
|
主題 |
bile acid |
| キーワード |
|
|
主題 |
cholic acid |
| キーワード |
|
|
主題 |
fibrosis |
| キーワード |
|
|
主題 |
gut microbiota |
| キーワード |
|
|
主題 |
inflammation |
| キーワード |
|
|
主題 |
macrophage |
| キーワード |
|
|
主題 |
metronidazole |
| キーワード |
|
|
主題 |
non-alcoholic steatohepatitis |
| キーワード |
|
|
主題 |
vancomycin |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 24,
号 4,
p. 4050,
発行日 2023-02-17
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14220067 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
395436 |
| 言語 |
|
|
言語 |
eng |
ijms_24_4_4050.pdf (4.48 MB)
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