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QTc Shortening on Electrocardiogram With Amitriptyline May Indicate No Effect on Pain Relief in Burning Mouth Syndrome
https://tokushima-u.repo.nii.ac.jp/records/2011589
https://tokushima-u.repo.nii.ac.jp/records/2011589f74a72ab-b4bf-46e8-bbd6-e9e209e934b0
| 名前 / ファイル | ライセンス | アクション |
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cn_47_2_33.pdf (338 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2024-02-15 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1097/WNF.0000000000000583 | |||||||||||||||||||||||
| 関連名称 | 10.1097/WNF.0000000000000583 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | QTc Shortening on Electrocardiogram With Amitriptyline May Indicate No Effect on Pain Relief in Burning Mouth Syndrome | |||||||||||||||||||||||
| 著者 |
ナガミネ, タカヒコ
× ナガミネ, タカヒコ
× 渡邊, 毅
WEKO
1454
× トヨフク, アキラ
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| 内容記述 | Objective: Burning mouth syndrome (BMS) is an intractable chronic pain disorder characterized by a burning sensation without organic abnormalities in the oral mucosa. Amitriptyline may be effective for BMS or, conversely, may exacerbate pain. QTc is necessary for monitoring psychotropic side effects, but it is not known if it is a predictor of efficacy for BMS. We investigated the efficacy of amitriptyline in BMS and its effect on QTc. Methods: Visual Analogue Scale (VAS) and electrocardiogram (ECG) were examined before and one month after treatment in 51 consecutive patients diagnosed with BMS according to the International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria and treated with amitriptyline. Results: There were 26 amitriptyline responders and 25 non-responders, with no differences in age, gender, and amitriptyline dosage. Amitriptyline responders showed little change in QTc, while non-responders showed a trend toward significantly shorter QTc. Changes in VAS correlated statistically significantly with changes in QTc (Spearman's rank correlation coefficient: 0384; p=0.0054). The degree of pain tended to worsen with QTc shortening. Conclusion: Amitriptyline provides analgesia in about half of BMS patients, but some BMS patients have worse pain with amitriptyline. Changes in the QTc not only detect amitriptyline side effects with prolongation, but conversely its shortening predicts amitriptyline ineffectiveness. |
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| キーワード | ||||||||||||||||||||||||
| 主題 | amitriptyline | |||||||||||||||||||||||
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| 主題 | burning mouth syndrome | |||||||||||||||||||||||
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| 主題 | QTc | |||||||||||||||||||||||
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| 主題 | serotonin paradox | |||||||||||||||||||||||
| 書誌情報 |
en : Clinical Neuropharmacology 巻 47, 号 2, p. 33-36, 発行日 2024-01-29 |
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| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 03625664 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 1537162X | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA00143342 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Wolters Kluwer Health | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical Neuropharmacology. The published version of record Nagamine, Takahiko MD, PhD; Watanabe, Takeshi DDS, PhD; Toyofuku, Akira DDS, PhD. QTc Shortening on Electrocardiogram With Amitriptyline May Indicate No Effect on Pain Relief in Burning Mouth Syndrome. Clinical Neuropharmacology (): 10.1097/WNF.0000000000000583, January 29, 2024. is available online at: https://doi.org/10.1097/WNF.0000000000000583. | |||||||||||||||||||||||
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| 識別子 | 404855 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
