| Item type |
文献 / Documents(1) |
| 公開日 |
2024-01-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/ijms232113251 |
|
|
関連名称 |
10.3390/ijms232113251 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis |
| 著者 |
タダ, ユウキ
カサイ, カイチ
マキウチ, ナナ
イガラシ, ナオヤ
カニ, コウダイ
タカノ, シュン
ホンダ, ヒロエ
ヤナギバシ, ツトム
ワタナベ, ヤスハル
ウスイ カワニシ, フミタケ
| ja |
ウスイ カワニシ, フミタケ
|
| ja-Kana |
ウスイ カワニシ, フミタケ
|
| en |
Usui-Kawanishi, Fumitake
|
Search repository
フルサワ, ユキヒロ
(市村)清水, 真祐子
タブチ, ヨシアキ
タカツ, キヨシ
常山, 幸一
ナガイ, ヨシノリ
|
| 抄録 |
|
|
内容記述 |
Macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). However, it is unclear which macrophage subsets are critically involved in the development of inflammation and fibrosis in NASH. In TSNO mice fed a high-fat/cholesterol/cholate-based diet, which exhibit advanced liver fibrosis that mimics human NASH, we found that Kupffer cells (KCs) were less abundant and recruited macrophages were more abundant, forming hepatic crown-like structures (hCLS) in the liver. The recruited macrophages comprised two subsets: CD11c+/Ly6C−and CD11c− /Ly6C+ cells. CD11c+ cells were present in a mesh-like pattern around the lipid droplets, constituting the hCLS. In addition, CD11c+ cells colocalized with collagen fibers, suggesting that this subset of recruited macrophages might promote advanced liver fibrosis. In contrast, Ly6C+cells were present in doughnut-like inflammatory lesions, with a lipid droplet in the center. Finally, RNA sequence analysis indicates that CD11c+/Ly6C− cells promote liver fibrosis and hepatic stellate cell (HSC) activation, whereas CD11c−/Ly6C+ cells are a macrophage subset that play an anti-inflammatory role and promote tissue repair in NASH. Taken together, our data revealed changes in liver macrophage subsets during the development of NASH and shed light on the roles of the recruited macrophages in the pathogenesis of advanced fibrosis in NASH. |
| キーワード |
|
|
主題 |
Kupffer cell |
| キーワード |
|
|
主題 |
fibrosis |
| キーワード |
|
|
主題 |
inflammation |
| キーワード |
|
|
主題 |
macrophage |
| キーワード |
|
|
主題 |
non-alcoholic fatty liver disease |
| キーワード |
|
|
主題 |
non-alcoholic steatohepatitis |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 23,
号 21,
p. 13251,
発行日 2022-10-31
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14220067 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
395819 |
| 言語 |
|
|
言語 |
eng |
ijms_23_21_13251.pdf (1.49 MB)
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