| Item type |
文献 / Documents(1) |
| 公開日 |
2024-01-29 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.celrep.2023.112454 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.celrep.2023.112454 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria |
|
言語 |
en |
| 著者 |
アカバネ, シオリ
ワタナベ, キヨナ
小迫, 英尊
ヤマシタ, シュンイチ
ニシノ, コウヘイ
カトウ, マサヒロ
セキネ, シオリ
カンキ, トモタケ
マツダ, ノリユキ
エンドウ, トシヤ
オカ, トシヒコ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
PINK1 is activated by autophosphorylation and forms a high-molecular-weight complex, thereby initiating the selective removal of damaged mitochondria by autophagy. Other than translocase of the outer mitochondrial membrane complexes, members of PINK1-containing protein complexes remain obscure. By mass spectrometric analysis of PINK1 co-immunoprecipitates, we identify the inner membrane protein TIM23 as a component of the PINK1 complex. TIM23 downregulation decreases PINK1 levels and significantly delays autophosphorylation, indicating that TIM23 promotes PINK1 accumulation in response to depolarization. Moreover, inactivation of the mitochondrial protease OMA1 not only enhances PINK1 accumulation but also represses the reduction in PINK1 levels induced by TIM23 downregulation, suggesting that TIM23 facilitates PINK1 activation by safeguarding against degradation by OMA1. Indeed, deficiencies of pathogenic PINK1 mutants that fail to interact with TIM23 are partially restored by OMA1 inactivation. These findings indicate that TIM23 plays a distinct role in activating mitochondrial autophagy by protecting PINK1. |
|
言語 |
en |
| 書誌情報 |
en : Cell Reports
巻 42,
号 5,
p. 112454,
発行日 2023-05-08
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
22111247 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
396658 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
celrep_42_5_112454.pdf (5.63 MB)
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