| Item type |
文献 / Documents(1) |
| 公開日 |
2024-01-29 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.1038/s42003-023-04826-x |
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|
関連名称 |
10.1038/s42003-023-04826-x |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
RAB35 is required for murine hippocampal development and functions by regulating neuronal cell distribution |
| 著者 |
マエジマ, イクコ
ハラ, タイチ
ツカモト, サトシ
コイズミ, ヒロユキ
カワウチ, タケシ
アクザワ, トモコ
ヒライ, リカ
コバヤシ, ヒサエ
イソベ, イノヤ
エモト, カズオ
小迫, 英尊
サトウ, ケン
|
| 抄録 |
|
|
内容記述 |
RAB35 is a multifunctional small GTPase that regulates endocytic recycling, cytoskeletal rearrangement, and cytokinesis. However, its physiological functions in mammalian development remain unclear. Here, we generated Rab35-knockout mice and found that RAB35 is essential for early embryogenesis. Interestingly, brain-specific Rab35-knockout mice displayed severe defects in hippocampal lamination owing to impaired distribution of pyramidal neurons, although defects in cerebral cortex formation were not evident. In addition, Rab35-knockout mice exhibited defects in spatial memory and anxiety-related behaviors. Quantitative proteomics indicated that the loss of RAB35 significantly affected the levels of other RAB proteins associated with endocytic trafficking, as well as some neural cell adhesion molecules, such as contactin-2. Collectively, our findings revealed that RAB35 is required for precise neuronal distribution in the developing hippocampus by regulating the expression of cell adhesion molecules, thereby influencing spatial memory. |
| 書誌情報 |
en : Communications Biology
巻 6,
p. 440,
発行日 2023-04-21
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
23993642 |
| 出版者 |
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出版者 |
Springer Nature |
| 権利情報 |
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|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
|
|
識別子 |
396659 |
| 言語 |
|
|
言語 |
eng |
cb_6_440.pdf (4.28 MB)
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