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Astaxanthin Exerts Immunomodulatory Effect by Regulating SDH-HIF-1α Axis and Reprogramming Mitochondrial Metabolism in LPS-Stimulated RAW264.7 Cells
https://tokushima-u.repo.nii.ac.jp/records/2011652
https://tokushima-u.repo.nii.ac.jp/records/201165201fb8706-f728-491c-9ea3-f30d930c04e0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
md_20_11_660.pdf (1.21 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||
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| 公開日 | 2024-02-05 | |||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/md20110660 | |||||||||||||||||||||||||||
| 関連名称 | 10.3390/md20110660 | |||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||
| タイトル | Astaxanthin Exerts Immunomodulatory Effect by Regulating SDH-HIF-1α Axis and Reprogramming Mitochondrial Metabolism in LPS-Stimulated RAW264.7 Cells | |||||||||||||||||||||||||||
| 著者 |
Sun, Luchuanyang
× Sun, Luchuanyang
× Kim, Sangeun
× モリ, リョウイチ
× ミヤジ, ノブユキ
× 二川, 健
WEKO
1586
× 平坂, 勝也 |
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| 抄録 | ||||||||||||||||||||||||||||
| 内容記述 | Astaxanthin (AX) is a carotenoid that exerts potent antioxidant activity and acts in cell membranes and mitochondria, which consist of the bilayer molecules. Targeting mitochondria to ameliorate inflammatory diseases by regulating mitochondrial metabolism has become possible and topical. Although AX has been shown to have anti-inflammatory effects in various cells, the mechanisms are quite different. In particular, the role of AX on mitochondrial metabolism in macrophages is still unknown. In this study, we investigated the effect of AX on mitochondria-mediated inflammation and its mechanisms in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. AX attenuated the mitochondrial O2− production and maintained the mitochondrial membrane potential, implying that AX preserved mitochondrial homeostasis to avoid LPS stimulation-induced mitochondrial dysfunction. Additionally, AX prevented the decrease in mitochondrial complexes I, II, and III, which were caused by LPS stimulation. Especially, AX inhibited the reduction in mitochondrial succinate dehydrogenase (SDH; complex II) activity and upregulated the protein and mRNA level of SDH complex, subunit B. Furthermore, AX blocked the IL-1β expression by regulating the SDH-HIF-1α axis and suppressed the energy shift from an OXPHOS phenotype to a glycolysis phenotype. These findings revealed important effects of AX on mitochondrial enzymes as well as on mitochondrial energy metabolism in the immune response. In addition, these raised the possibility that AX plays an important role in other diseases caused by SDH mutation and metabolic disorders. | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | astaxanthin | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | mitochondrial ROS | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | mitochondrial energy metabolism | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | mitochondrial succinate dehydrogenase | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | hypoxia-inducible factor-1α | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | interleukin-1β | |||||||||||||||||||||||||||
| 書誌情報 |
en : Marine Drugs 巻 20, 号 11, p. 660, 発行日 2022-10-25 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 16603397 | |||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||
| 権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||||
| 識別子 | 396752 | |||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||
