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Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla

https://tokushima-u.repo.nii.ac.jp/records/2011661
https://tokushima-u.repo.nii.ac.jp/records/2011661
755b8a25-f4c6-4d62-bf9b-d0c6fbda919e
名前 / ファイル ライセンス アクション
ncomms_14_2066.pdf ncomms_14_2066.pdf (8.2 MB)
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Item type 文献 / Documents(1)
公開日 2024-03-15
アクセス権
アクセス権 open access
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版社版DOI
関連識別子 https://doi.org/10.1038/s41467-023-37589-4
関連名称 10.1038/s41467-023-37589-4
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
タイトル
タイトル Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla
著者 Lucas, Beth

× Lucas, Beth

en Lucas, Beth

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White, Andrea J.

× White, Andrea J.

en White, Andrea J.

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Klein, Fabian

× Klein, Fabian

en Klein, Fabian

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Veiga-Villauriz, Clara

× Veiga-Villauriz, Clara

en Veiga-Villauriz, Clara

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Handel, Adam

× Handel, Adam

en Handel, Adam

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Bacon, Andrea

× Bacon, Andrea

en Bacon, Andrea

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Cosway, Emilie J.

× Cosway, Emilie J.

en Cosway, Emilie J.

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James, Kieran D.

× James, Kieran D.

en James, Kieran D.

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Parnell, Sonia M.

× Parnell, Sonia M.

en Parnell, Sonia M.

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大東, いずみ

× 大東, いずみ

WEKO 424
徳島大学 教育研究者総覧 207340/profile-ja.html
e-Rad 00596588

ja 大東, いずみ
ISNI

ja-Kana オオヒガシ, イズミ

en Ohigashi, Izumi

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高浜, 洋介

× 高浜, 洋介

WEKO 1519
徳島大学 教育研究者総覧 60028/profile-ja.html
e-Rad_Researcher 20183858

ja 高浜, 洋介
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ja-Kana タカハマ, ヨウスケ

en Takahama, Yousuke

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Jenkinson, William E.

× Jenkinson, William E.

en Jenkinson, William E.

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Hollander, Georg A.

× Hollander, Georg A.

en Hollander, Georg A.

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Lu, Wei-Yu

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Anderson, Graham

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抄録
内容記述 The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of the medulla for thymus function is clear, the production and maintenance of mTEC diversity remains poorly understood. Here, using ontogenetic and inducible fate-mapping approaches, we identify mTEC-restricted progenitors as a cytokeratin19+ (K19+) TEC subset that emerges in the embryonic thymus. Importantly, labelling of a single cohort of K19+ TEC during embryogenesis sustains the production of multiple mTEC subsets into adulthood, including CCL21+ mTEClo, Aire+ mTEChi and thymic tuft cells. We show K19+ progenitors arise prior to the acquisition of multiple mTEC-defining features including RANK and CCL21 and are generated independently of the key mTEC regulator, Relb. In conclusion, we identify and define a multipotent mTEC progenitor that emerges during embryogenesis to support mTEC diversity into adult life.
書誌情報 en : Nature Communications

巻 14, p. 2066, 発行日 2023-04-12
収録物ID
収録物識別子タイプ ISSN
収録物識別子 20411723
収録物ID
収録物識別子タイプ NCID
収録物識別子 AA12645905
出版者
出版者 Springer Nature
権利情報
権利情報 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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