| Item type |
文献 / Documents(1) |
| 公開日 |
2024-04-01 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s41467-023-36189-6 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1038/s41467-023-36189-6 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid–liquid phase separation |
|
言語 |
en |
| 著者 |
ホリイ, ユウマ
マツダ, ショウイチ
トヨタ, チカシ
モリナガ, タクミ
ナカヤ, タケオ
ツチヤ, ソウケン
オオムラヤ, マサキ
ヒロナカ, タカノリ
ヨシキ, リョウ
カサイ, コウタロウ
ヤマウチ, ユウト
タキザワ, ノブロウ
ナガサカ, アキオミ
タナカ, アキラ
小迫, 英尊
ナカヤ, ミチオ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Myofibroblasts cause tissue fibrosis by producing extracellular matrix proteins, such as collagens. Humoral factors like TGF-β, and matrix stiffness are important for collagen production by myofibroblasts. However, the molecular mechanisms regulating their ability to produce collagen remain poorly characterised. Here, we show that vestigial-like family member 3 (VGLL3) is specifically expressed in myofibroblasts from mouse and human fibrotic hearts and promotes collagen production. Further, substrate stiffness triggers VGLL3 translocation into the nucleus through the integrin β1-Rho-actin pathway. In the nucleus, VGLL3 undergoes liquid-liquid phase separation via its low-complexity domain and is incorporated into non-paraspeckle NONO condensates containing EWS RNA-binding protein 1 (EWSR1). VGLL3 binds EWSR1 and suppresses miR-29b, which targets collagen mRNA. Consistently, cardiac fibrosis after myocardial infarction is significantly attenuated in Vgll3-deficient mice, with increased miR-29b expression. Overall, our results reveal an unrecognised VGLL3-mediated pathway that controls myofibroblasts’ collagen production, representing a novel therapeutic target for tissue fibrosis. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 14,
p. 550,
発行日 2023-02-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20411723 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
|
|
識別子 |
396656 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ncomms_14_550.pdf (5.47 MB)
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