| Item type |
文献 / Documents(1) |
| 公開日 |
2024-04-01 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1038/s41467-022-29978-y |
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|
関連名称 |
10.1038/s41467-022-29978-y |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift |
| 著者 |
Zhang, Yang
Garcia-Ibanez, Laura
Ulbricht, Carolin
Lok, Laurence S. C.
Pike, Jeremy A.
Mueller-Winkler, Jennifer
Dennison, Thomas W.
Ferdinand, John R.
Burnett, Cameron J. M.
Yam-Puc, Juan C.
Zhang, Lingling
Maqueda Alfaro, Raul
高浜, 洋介
大東, いずみ
Brown, Geoffrey
クロサキ, トモヒロ
Tybulewicz, Victor L. J.
Rot, Antal
Hauser, Anja E.
Clatworthy, Menna R.
Toellner, Kai-Michael
|
| 抄録 |
|
|
内容記述 |
Infection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing antibody-forming plasma cells or memory B cells. Here we follow the migratory pathways of B cells emerging from germinal centers (BEM) and find that many BEM cells migrate into the lymph node subcapsular sinus (SCS) guided by sphingosine-1-phosphate (S1P). From the SCS, BEM cells may exit the lymph node to enter distant tissues, while some BEM cells interact with and take up antigen from SCS macrophages, followed by CCL21-guided return towards the GC. Disruption of local CCL21 gradients inhibits the recycling of BEM cells and results in less efficient adaption to antigenic variation. Our findings thus suggest that the recycling of antigen variant-specific BEM cells and transport of antigen back to GC may support affinity maturation to antigenic drift. |
| 書誌情報 |
en : Nature Communications
巻 13,
p. 2460,
発行日 2022-05-05
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20411723 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利情報 |
|
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
|
|
識別子 |
394963 |
| 言語 |
|
|
言語 |
eng |
ncomms_13_2460.pdf (8.32 MB)
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