| Item type |
文献 / Documents(1) |
| 公開日 |
2024-02-26 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.heliyon.2023.e16978 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.heliyon.2023.e16978 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Establishment of repeated liver biopsy technique in experimental mice |
|
言語 |
en |
| 著者 |
卲, 文華
(市村)清水, 真祐子
小川, 博久
Jin, Shengjian
ストウ, ミツコ
ナカムラ, サトコ
オノデラ, ミキ
タワラ, ヒロスケ
トヨハラ, シュンジ
ホカオ, リョウジ
工藤, 保誠
尾矢, 剛志
常山, 幸一
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Biopsy is a commonly used method for determining pathological diagnoses by directly using human tissues and cells. Biopsies are widely used to determine disease progression and treatment efficacy. Although organs and tissues are usually obtained by sacrifice during animal experiments, it is theoretically possible to use the same biopsy techniques in humans. In the present study, we examined the feasibility of performing four repeated liver biopsies in a spontaneous metabolic syndrome mouse model. Even though a small number of mice died accidently, most mice were able to undergo four liver biopsies without significant adverse events. We also performed three liver biopsies in mouse liver tumor carcinogen models at 4, 8, and 12 weeks of age. In addition to the sample collected at 16 weeks of age during sacrifice, we successfully collected four liver samples from the same mice at different stages of disease progression. The application of this liver biopsy technique might make it possible for direct evaluation of pathological conditions in the same individual over time, thereby reducing the number of experimental animals. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Liver biopsy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Metabolic syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Mouse model |
| 書誌情報 |
en : Heliyon
巻 9,
号 6,
p. e16978,
発行日 2023-06-03
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
24058440 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
401770 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
heliyon_9_6_e16978.pdf (2.67 MB)
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