| Item type |
文献 / Documents(1) |
| 公開日 |
2024-07-17 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.oret.2022.02.008 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.oret.2022.02.008 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Foveal Thickness Fluctuation in Anti-VEGF Treatment for Branch Retinal Vein Occlusion : A Long-term Study |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
FTF in Anti-VEGF Treatment for BRVO |
|
言語 |
en |
| 著者 |
ナガサト, ダイスケ
ムラオカ, ユウキ
タナベ, マオ
ニシゴリ, ナオミ
オオサカ, リエ
三田村, 佳典
タブチ, ヒトシ
カドモト, シン
ムラカミ, トモアキ
オオオト, ソウタロウ
スズマ, キヨシ
ツジカワ, アキタカ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Branch retinal vein occlusion (BRVO) causes macular edema (ME), which can be controlled with anti-VEGF treatments. However, these treatments are not curative, necessitating additional anti-VEGF treatments at recurrence. Long-term results, optimal anti-VEGF treatment regimens, and the comprehensive effects of ME recurrence are largely unknown. Thus, we aimed to examine the effects of foveal thickness (FT) fluctuation (FTF) on the visual and morphologic outcomes of anti-VEGF treatments for BRVO-ME administered via a pro re nata regimen.
Design: A retrospective, observational case series.
Subjects: This study analyzed 309 treatment-naïve patients (309 eyes) with BRVO-ME between 2012 and 2021 at a multicenter retinal practice.
Methods: The FT was assessed using OCT at each study visit.
Main Outcome Measures: We evaluated the logarithm of the minimal angle of resolution (logMAR) best corrected visual acuity (BCVA) and the defect length of the foveal ellipsoid zone (EZ) band using OCT.
Results: At baseline, the mean logMAR BCVA was 0.30 ± 0.30 and the mean FT was 503 ± 162 μm. The number of anti-VEGF injections for BRVO-ME was 5.8 ± 4.6 during the mean follow-up period (50.6 ± 22.2 months). At the final examination, the mean logMAR BCVA and FT values were significantly improved compared with those at the baseline. Multiple regression analyses showed that age, baseline logMAR BCVA, and FTF were significantly associated with the final logMAR BCVA (β = 0.20, 0.35, and 0.30, respectively). Foveal thickness fluctuation (divided into groups 0–3 in ascending order of FTF) was significantly associated with logMAR BCVA and the defect length of the foveal EZ band at the final examination. The defect lengths of the foveal EZ band were longitudinally shortened in groups 0 and 1 and were slightly prolonged in groups 2 and 3. The logMAR BCVA showed improvements in groups 0 and 1 and worsened slightly in groups 2 and 3.
Conclusions: Foveal thickness fluctuation was significantly associated with visual acuity and foveal photoreceptor status. Thus, the morphologic and functional prognoses of eyes with BRVO may improve with the identification of the characteristics of eyes with greater FTF and consequently controlling the FTF more strictly. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
A long-term multicenter study |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Anti-VEGF treatment |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Branch retinal vein occlusion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Foveal thickness fluctuation |
| 書誌情報 |
en : Ophthalmology Retina
巻 6,
号 7,
p. 567-574,
発行日 2022-02-24
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
24686530 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
24687219 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
395913 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
oret_6_7_567.pdf (923 KB)
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