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Discretizing low-intensity whole-body vibration into bouts with short rest intervals promotes bone defect repair in osteoporotic mice
https://tokushima-u.repo.nii.ac.jp/records/2011696
https://tokushima-u.repo.nii.ac.jp/records/2011696b5b8d0ad-dbc7-454a-8ffe-d9cb8374310d
| 名前 / ファイル | ライセンス | アクション |
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jor_42_6_1267.pdf (1.67 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2024-02-29 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1002/jor.25781 | |||||||||||||||||||||||
| 関連名称 | 10.1002/jor.25781 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Discretizing low-intensity whole-body vibration into bouts with short rest intervals promotes bone defect repair in osteoporotic mice | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | Vibration bouts with short rests | |||||||||||||||||||||||
| 著者 |
松本, 健志
× 松本, 健志
WEKO
765
× ハシモト, ケイシ
× オカダ, ヒュウガ
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| 内容記述 | Continuous administration of low-intensity whole-body vibration (WBV) gradually diminishes bone mechanosensitivity over time, leading to a weakening of its osteogenic effect. We investigated whether discretizing WBV into bouts with short rest intervals was effective in enhancing osteoporotic bone repair. Ten-week-old female mice were ovariectomized and underwent drill-hole defect surgery (day 0) on the right tibial diaphysis at 11 weeks of age. The mice underwent one of three regimens starting from day 1 for 5 days/week: continuous WBV at 45 Hz and 0.3 g for 7.5 minutes/day (cWBV); 3-second bouts of WBV at 45 Hz, 0.3 g followed by 9-second rest intervals, repeated for 30 minutes/day (rWBV); or a sham treatment. Both the cWBV and rWBV groups received a total of 20,250 vibration cycles per day. On either day 7 or 14 post-euthanasia (n = 6/group/timepoint), the bone and angiogenic vasculature in the defect were CT imaged using synchrotron lights. By day 14, the bone repair was most advanced in the rWBV group, showing a higher bone volume fraction and a more uniform mineral distribution compared with the sham group. The cWBV group exhibited an intermediate level of bone repair between the sham and rWBV groups. The rWBV group had a decrease in large-sized angiogenic vessels, while the cWBV group showed an increase in such vessels. In conclusion, osteoporotic bone repair was enhanced by WBV bouts with short rest intervals, which may potentially be attributed to the improved mechanosensitivity of osteogenic cells and alterations in angiogenic vasculature. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | angiogenic vasculature | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | bone repair | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | mechanosensitivity | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | osteoporosis | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | whole-body vibration | |||||||||||||||||||||||
| 書誌情報 |
en : Journal of Orthopaedic Research 巻 42, 号 6, p. 1267-1275, 発行日 2024-01-17 |
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| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 1554527X | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 07360266 | |||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA10625350 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Wiley | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Orthopaedic Research Society | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | This is the peer reviewed version of the following article: Matsumoto, T, Hashimoto, K, Okada, H, Discretizing low-intensity whole-body vibration into bouts with short rest intervals promotes bone defect repair in osteoporotic mice. Journal of Orthopaedic Research, 42, 6, 1267-1275., which has been published in final form at https://doi.org/10.1002/jor.25781. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | |||||||||||||||||||||||
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| 識別子 | 405039 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
