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Effects of ferulic acid combined with light irradiation on deoxynivalenol and its production in Fusarium graminearum
https://tokushima-u.repo.nii.ac.jp/records/2011759
https://tokushima-u.repo.nii.ac.jp/records/201175914b8af15-f0b8-4373-b3b5-426c5ba9dc65
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
funbio_128_2_1684.pdf (572 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||
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| 公開日 | 2024-02-29 | |||||||||||||||||
| アクセス権 | ||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版社版DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.funbio.2024.02.003 | |||||||||||||||||
| 関連名称 | 10.1016/j.funbio.2024.02.003 | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Effects of ferulic acid combined with light irradiation on deoxynivalenol and its production in Fusarium graminearum | |||||||||||||||||
| 著者 |
白井, 昭博
× 白井, 昭博
WEKO
1235
× タナカ, アミ
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| 抄録 | ||||||||||||||||||
| 内容記述 | This study aimed to investigate the effects of ferulic acid (FA), a natural phenolic phytochemical, in combination with light irradiation at three wavelengths (365, 385 and 405 nm) on the concentration and toxicity of deoxynivalenol (DON), a mycotoxin produced by Fusarium graminearum. Moreover, this study examined the influence of the combination treatment on DON production in the cultured fungus. FA activated by light at a peak wavelength of 365 nm exhibited the most effective decrease in DON concentration of the tested wavelengths; a residual DON ratio of 0.23 at 24 h exposure was observed, compared with the initial concentration. The reduction in DON using 365-nm light was dependent on the concentration of FA, with a good correlation (r2=0.979) between the rate constants of DON decrease and FA concentration, which was confirmed by a pseudo-first-order kinetics analysis of the photoreaction with different FA concentrations (50 to 400 mg/L) for 3 h. The viability of HepG2 cells increased by 56.7% following in vitro treatment with a mixture containing the photoproducts obtained after treatment with 20 mg/L DON and 200 mg/L FA under 365-nm irradiation for 6 h. These results suggested that the photoreaction of FA under 365-nm irradiation induces the detoxification of DON through degradation or modification of DON. The antifungal effects of the combination (FA and 365-nm light) on F. graminearum were investigated. Conidia treated with the combination did not show additive or synergistic inhibition of fungal biomass and DON production in 7-day cultivated fungal samples compared with samples after single treatment. However, successive treatment, composed of 90 min irradiation at 365 nm and then treatment with 200 mg/L FA for 90 min in the dark, suppressed fungal growth and DON yield to 70% and 25% of the untreated sample level, respectively. This photo-technology involving the two treatment methods of 365-nm irradiation and FA addition as a food-grade phenolic acid in combination or successively, can aid in developing alternative approaches to eliminate fungal contaminants in the fields of environmental water and agriculture. However, further research is required to explore the underlying mechanisms of DON decontamination and its biosynthesis in F. graminearum. | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Deoxynivalenol | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Ferulic acid | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Light irradiation | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Cytotoxicity | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Antifungal assay | |||||||||||||||||
| 書誌情報 |
en : Fungal Biology 巻 128, 号 2, p. 1684-1690, 発行日 2024-02-10 |
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| 収録物ID | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 18786162 | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 18786146 | |||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA12469187 | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 権利情報 | © 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||
| EID | ||||||||||||||||||
| 識別子 | 405079 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
