| Item type |
文献 / Documents(1) |
| 公開日 |
2024-04-04 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/biomedicines11113020 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/biomedicines11113020 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Cross-Sectional and Longitudinal Associations between Skin Autofluorescence and Tubular Injury Defined by Urinary Excretion of Liver-Type Fatty Acid-Binding Protein in People with Type 2 Diabetes |
|
言語 |
en |
| 著者 |
山上, 紘規
原, 倫世
ヤスイ, サヤ
ホソキ, ミナエ
ホリ, タイキ
カネコ, ヨウスケ
ミツイ, ユカリ
倉橋, 清衛
原田, 武志
吉田, 守美子
中村, 信元
乙田, 敏城
湯浅, 智之
黒田, 暁生
遠藤, 逸朗
松久, 宗英
安倍, 正博
粟飯原, 賢一
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
It has previously been unclear whether the accumulation of advanced glycation end products, which can be measured using skin autofluorescence (SAF), has a significant role in diabetic kidney disease (DKD), including glomerular injury and tubular injury. This study was therefore carried out to determine whether SAF correlates with the progression of DKD in people with type 2 diabetes (T2D). In 350 Japanese people with T2D, SAF values were measured using an AGE Reader®, and both urine albumin-to-creatinine ratio (uACR), as a biomarker of glomerular injury, and urine liver-type fatty acid-binding protein (uLFABP)-to-creatinine ratio (uL-FABPCR), as a biomarker of tubular injury, were estimated as indices of the severity of DKD. Significant associations of SAF with uACR (p < 0.01), log-transformed uACR (p < 0.001), uL-FABPCR (p < 0.001), and log-transformed uL-FABPCR (p < 0.001) were found through a simple linear regression analysis. Although SAF was positively associated with increasing uL-FABPCR (p < 0.05) and increasing log-transformed uL-FABPCR (p < 0.05), SAF had no association with increasing uACR or log-transformed uACR after adjusting for clinical confounding factors. In addition, the annual change in SAF showed a significant positive correlation with annual change in uL-FABPCR regardless of confounding factors (p = 0.026). In conclusion, SAF is positively correlated with uL-FABP but not with uACR in people with T2D. Thus, there is a possibility that SAF can serve as a novel predictor for the development of diabetic tubular injury. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
skin autofluorescence |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
type 2 diabetes |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
diabetic kidney disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
albuminuria |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tubular injury |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
L-FABP |
| 書誌情報 |
en : Biomedicines
巻 11,
号 11,
p. 3020,
発行日 2023-11-10
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
22279059 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
405468 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
biomed_11_11_3020.pdf (1.63 MB)
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