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生命金属元素鉄の新たな役割と治療応用
https://tokushima-u.repo.nii.ac.jp/records/2011859
https://tokushima-u.repo.nii.ac.jp/records/2011859e87feaa9-6ca0-4da2-b5c5-c4263ddf03c4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
sam_79_5-6_229.pdf (4.68 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2024-04-16 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.57444/shikokuactamedica.79.5.6_229 | |||||||||||
| 関連名称 | 10.57444/shikokuactamedica.79.5.6_229 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 生命金属元素鉄の新たな役割と治療応用 | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | Novel role of the biometal element iron in the development of therapeutic strategies | |||||||||||
| 著者 |
池田, 康将
× 池田, 康将
WEKO
482
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| 抄録 | ||||||||||||
| 内容記述 | Iron is the most abundant trace metal and indispensable for the biogenicity of living organisms. Iron deficiency anemia is often observed in iron-related disorders, and therefore, proactive iron intake is recommended. In contrast, iron causes oxidative stress by catalyzing the Fenton reaction. Recent evidence suggests that iron is involved in the pathophysiology of non-iron-accumulating diseases, and the role of iron has been revisited. In the last three decades, many studies have shown that iron content is associated with diabetes and that high iron intake increases the risk of diabetes onset. Iron reduction by phlebotomy or iron chelators ameliorates insulin sensitivity and secretion. Several studies have shown that high iron levels are also associated with obesity. Therefore, we speculate that iron reduction could exert a favorable effect on obesity. As expected, iron chelators mitigated obesity by inhibiting inflammatory cytokines and oxidative stress in KKAy mice. We advocate that “iron stress” is related to iron-dependent inflammation and oxidative stress, and have reported that iron stress is involved in kidney disease, sarcopenia, vascular dysfunction, and so on. However, non-specific iron reduction always causes iron-deficient adverse effects, such as anemia, and it is difficult to adopt a clinical application. Macrophage plays a critical role in chronic inflammation including obesity and diabetes. M1 inflammatory macrophages exhibit an iron-retention phenotype with elevated H-ferritin（ FTH） expression. Mice with macrophage-specific FTH deletion（FTHKO） showed reduced iron concentrations in macrophages, without anemia. HFD- induced obesity and diabetes were alleviated in FTHKO mice by inhibiting inflammation and oxidative stress in adipose tissue, similar to the effect of systemic iron reduction. Therefore, macrophages are the main source of iron stress, leading to new therapeutic strategies for controlling the iron levels in macrophages. | |||||||||||
| キーワード | ||||||||||||
| 主題 | iron | |||||||||||
| キーワード | ||||||||||||
| 主題 | macrophage | |||||||||||
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| 主題 | inflammation | |||||||||||
| キーワード | ||||||||||||
| 主題 | oxidative stress | |||||||||||
| 書誌情報 |
ja : 四国医学雑誌 en : Shikoku Acta Medica 巻 79, 号 5-6, p. 229-236, 発行日 2024-03-11 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 00373699 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 27583279 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 徳島医学会 | |||||||||||
| EID | ||||||||||||
| 識別子 | 403245 | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
