| Item type |
文献 / Documents(1) |
| 公開日 |
2024-04-30 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.2176/nmc.oa.2016-0061 |
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|
言語 |
ja |
|
|
関連名称 |
10.2176/nmc.oa.2016-0061 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Histopathological Findings in Brains of Patients Who Died in the Acute Stage of Poor-grade Subarachnoid Hemorrhage |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Histopathological Findings in Brains with Poor-grade Subarachnoid Hemorrhage |
|
言語 |
en |
| 著者 |
里見, 淳一郎
ハデイシ, ヒロム
ヨシダ, ヤスジ
スズキ, アキフミ
永廣, 信治
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Patients with poor-grade aneurysmal subarachnoid hemorrhage (SAH) are likely to die due to irreversible acute-stage primary brain damage. However, the mechanism(s) and pathology responsible for their high mortality rate remain unclear. We report our findings on the brains of individuals who died in the acute stage of SAH. An autopsy was performed on the brains of 11 SAH patients (World Federation of Neurosurgical Societies grade 5) who died within 3 days of admission and who did not receive respiratory assistance. All brains were free of intracranial hematoma and hydrocephalus; all harbored ruptured aneurysms. In all brains, multiple infarcts with perifocal edema were scattered throughout the cortex and subcortical white matter of the whole brain. Infarcts with a patchy – were more often seen than infarcts with a wedge-shaped pattern. Microscopic examination revealed multiple areas with cytotoxic edema and neuronal death indicative of acute ischemic changes. Edema and congestion were more obvious in areas where the subarachnoid clot tightly adhered to the pia mater. Pathologically, the brains of deceased patients with acute poor-grade SAH were characterized by edema and multifocal infarcts spread throughout the whole brain; they were thought to be attributable to venous ischemia. Diffuse disturbance in venous drainage attributable to an abrupt increase in the intracranial pressure and focal disturbances due to tight adhesion of the subarachnoid clot to the pia mater, may contribute strongly to irreversible brain damage in the acute stage of SAH. |
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言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
histopathology of the brain |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
poor grade SAH |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
early brain injury |
| 書誌情報 |
en : Neurologia Medico-Chirurgica
巻 56,
号 12,
p. 766-770,
発行日 2016
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
04708105 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13498029 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00358613 |
| 出版者 |
|
|
出版者 |
The Japan Neurosurgical Society |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License. |
| EID |
|
|
識別子 |
316692 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
nmc_56_12_766.pdf (1.63 MB)
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