| Item type |
文献 / Documents(1) |
| 公開日 |
2024-06-14 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/ijms25042344 |
|
|
関連名称 |
10.3390/ijms25042344 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Anserine, a Histidine-Containing Dipeptide, Suppresses Pressure Overload-Induced Systolic Dysfunction by Inhibiting Histone Acetyltransferase Activity of p300 in Mice |
| 著者 |
スナガワ, ヨウイチ
ツカベ, リョウスケ
イロカワ, ユウダイ
船本, 雅文
スズキ, ユウト
ヤマダ, ミホ
シミズ, サトシ
カタナサカ, ヤスフミ
ハマベ ホリイケ, トシヒデ
| ja |
ハマベ ホリイケ, トシヒデ
|
| ja-Kana |
ハマベ ホリイケ, トシヒデ
|
| en |
Hamabe-Horiike, Toshihide
|
Search repository
カワセ, ユウト
ナルタ, リュウヤ
シミズ, カナ
モリ, キヨシ
ホソミ, リョウタ
コミヤマ, マキ
ハセガワ, コウジ
モリモト, タツヤ
|
| 抄録 |
|
|
内容記述 |
Anserine, an imidazole dipeptide, is present in the muscles of birds and fish and has various bioactivities, such as anti-inflammatory and anti-fatigue effects. However, the effect of anserine on the development of heart failure remains unknown. We cultured primary cardiomyocytes with 0.03 mM to 10 mM anserine and stimulated them with phenylephrine for 48 h. Anserine significantly suppressed the phenylephrine-induced increases in cardiomyocyte hypertrophy, ANF and BNP mRNA levels, and histone H3K9 acetylation. An in vitro histone acetyltransferase (HAT) assay showed that anserine directly suppressed p300-HAT activity with an IC50 of 1.87 mM. Subsequently, 8-week-old male C57BL/6J mice were subjected to transverse aortic constriction (TAC) and were randomly assigned to receive daily oral treatment with anserine-containing material, Marine Active® (60 or 200 mg/kg anserine) or vehicle for 8 weeks. Echocardiography revealed that anserine 200 mg/kg significantly prevented the TAC-induced increase in left ventricular posterior wall thickness and the decrease in left ventricular fractional shortening. Moreover, anserine significantly suppressed the TAC-induced acetylation of histone H3K9. These results indicate that anserine suppresses TAC-induced systolic dysfunction, at least in part, by inhibiting p300-HAT activity. Anserine may be used as a pharmacological agent for human heart failure therapy. |
| キーワード |
|
|
主題 |
anserine |
| キーワード |
|
|
主題 |
p300 |
| キーワード |
|
|
主題 |
histone acetyltransferase activity |
| キーワード |
|
|
主題 |
heart failure |
| キーワード |
|
|
主題 |
pressure overload |
| キーワード |
|
|
主題 |
cardiomyocyte hypertrophy |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 25,
号 4,
p. 2344,
発行日 2024-02-16
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14220067 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
405926 |
| 言語 |
|
|
言語 |
eng |
ijms_25_4_2344.pdf (2.84 MB)
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