| Item type |
文献 / Documents(1) |
| 公開日 |
2024-06-11 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1074/jbc.M116.734657 |
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|
言語 |
ja |
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|
関連名称 |
10.1074/jbc.M116.734657 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Expression and Function of Group IIE Phospholipase A2 in Mouse Skin |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
sPLA2-IIE, a Hair Follicular sPLA2 |
|
言語 |
en |
| 著者 |
山本, 圭
ミキ, ヨシミ
サトウ, ヒロヤス
ニシトウ, ヤスマサ
Gelb, Michael H.
タケトミ, ヨシタカ
ムラカミ, マコト
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Recent studies using knock-out mice for various secreted phospholipase A2 (sPLA2) isoforms have revealed their non-redundant roles in diverse biological events. In the skin, group IIF sPLA2 (sPLA2-IIF), an “epidermal sPLA2” expressed in the suprabasal keratinocytes, plays a fundamental role in epidermal-hyperplasic diseases such as psoriasis and skin cancer. In this study, we found that group IIE sPLA2 (sPLA2-IIE) was expressed abundantly in hair follicles and to a lesser extent in basal epidermal keratinocytes in mouse skin. Mice lacking sPLA2-IIE exhibited skin abnormalities distinct from those in mice lacking sPLA2-IIF, with perturbation of hair follicle ultrastructure, modest changes in the steady-state expression of a subset of skin genes, and no changes in the features of psoriasis or contact dermatitis. Lipidomics analysis revealed that sPLA2-IIE and -IIF were coupled with distinct lipid pathways in the skin. Overall, two skin sPLA2s, hair follicular sPLA2-IIE and epidermal sPLA2-IIF, play non-redundant roles in distinct compartments of mouse skin, underscoring the functional diversity of multiple sPLA2s in the coordinated regulation of skin homeostasis and diseases. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Biological Chemistry
巻 291,
号 30,
p. 15602-15613,
発行日 2016-05-23
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00219258 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1083351X |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1202441X |
| 出版者 |
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|
出版者 |
American Society for Biochemistry and Molecular Biology |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the CC BY license. |
| EID |
|
|
識別子 |
313727 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jbc_291_30_15602.pdf (2.71 MB)
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