| Item type |
文献 / Documents(1) |
| 公開日 |
2024-05-28 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
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資源タイプ |
doctoral thesis |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1152/ajprenal.00310.2023 |
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関連名称 |
10.1152/ajprenal.00310.2023 |
| 出版タイプ |
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出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
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タイトル |
Elevated luminal inorganic phosphate suppresses intestinal Zn absorption in 5/6 nephrectomized rats |
| タイトル別表記 |
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その他のタイトル |
5/6腎臓摘出ラットにおいて増加する腸管腔内無機リン酸は亜鉛吸収を抑制する |
| タイトル別表記 |
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その他のタイトル |
INORGANIC PHOSPHATE SUPPRESSES INTESTINAL Zn ABSORPTION |
| 著者 |
奥村, 陽介
アベ, コウタロウ
サカイ, ショウコ
亀井, 優輝
モリ, ユウキ
アダチ, ユウイチロウ
タキカワ, マサキ
キタムラ, アヤノ
大南, 博和
大西, 康太
増田, 真志
カンベ, タイホウ
山本, 浩範
竹谷, 豊
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| 抄録 |
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内容記述 |
Zinc (Zn) is an essential trace element in various biological processes. Chronic kidney disease (CKD) often leads to hypozincemia, resulting in further progression of CKD. In CKD, intestinal Zn absorption, the main regulator of systemic Zn metabolism, is often impaired; however, the mechanism underlying Zn malabsorption remains unclear. Here, we evaluated intestinal Zn absorption capacity in a rat model of CKD induced by 5/6 nephrectomy (5/6 Nx). Rats were given Zn and the incremental area under the plasma Zn concentration-time curve (iAUC) was measured as well as the expression of ZIP4, an intestinal Zn transporter. We found that 5/6 Nx rats showed lower iAUC than sham-operated rats, but expression of ZIP4 protein was upregulated. We therefore focused on other Zn absorption regulators to explore the mechanism by which Zn absorption was substantially decreased. Because some phosphate compounds inhibit Zn absorption by coprecipitation and hyperphosphatemia is a common symptom in advanced CKD, we measured inorganic phosphate (Pi) levels. Pi was elevated in not only serum but also the intestinal lumen of 5/6 Nx rats. Furthermore, intestinal intraluminal Pi administration decreased the iAUC in a dose-dependent manner in normal rats. In vitro, increased Pi concentration decreased Zn solubility under physiological conditions. Furthermore, dietary Pi restriction ameliorated hypozincemia in 5/6 Nx rats. We conclude that hyperphosphatemia or excess Pi intake is a factor in Zn malabsorption and hypozincemia in CKD. Appropriate management of hyperphosphatemia will be useful for prevention and treatment of hypozincemia in patients with CKD.
NEW & NOTEWORTHY We demonstrated that elevated intestinal luminal Pi concentration can suppress intestinal Zn absorption activity without decreasing the expression of the associated Zn transporter. Increased intestinal luminal Pi led to the formation of an insoluble complex with Zn while dietary Pi restriction or administration of a Pi binder ameliorated hypozincemia in chronic kidney disease model rats. Therefore, modulation of dietary Pi by Pi restriction or a Pi binder might be useful for the treatment of hypozincemia and hyperphosphatemia. |
| キーワード |
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主題 |
chronic kidney disease |
| キーワード |
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主題 |
zinc deficiency |
| キーワード |
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|
主題 |
hyperphosphatemia |
| キーワード |
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主題 |
dietary phosphate |
| キーワード |
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主題 |
zinc transporter |
| 書誌情報 |
en : American Journal of Physiology-Renal Physiology
巻 326,
号 3,
p. F411-F419,
発行日 2024-02-21
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1931857X |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15221466 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11118857 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12070596 |
| 出版者 |
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出版者 |
American Physiological Society |
| 備考 |
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値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Yosuke Okumuraの学位論文として提出され，学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院医科栄養学研究科（医科栄養学専攻） |
| EID |
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識別子 |
407641 |
| 言語 |
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言語 |
eng |
| 報告番号 |
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学位授与番号 |
甲第3807号 |
| 学位記番号 |
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値 |
甲栄第306号 |
| 学位授与年月日 |
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学位授与年月日 |
2024-03-22 |
| 学位名 |
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学位名 |
博士（栄養学） |
| 学位授与機関 |
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学位授与機関名 |
徳島大学 |
k3807_abstract_review.pdf (226 KB)
