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Curcumin and Andrographis Exhibit Anti-Tumor Effects in Colorectal Cancer via Activation of Ferroptosis and Dual Suppression of Glutathione Peroxidase-4 and Ferroptosis Suppressor Protein-1
https://tokushima-u.repo.nii.ac.jp/records/2012092
https://tokushima-u.repo.nii.ac.jp/records/20120929a02ba46-19c2-4e57-a129-459174e089b7
| 名前 / ファイル | ライセンス | アクション |
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ph_16_3_383.pdf (3.03 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2024-07-18 | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/ph16030383 | |||||||||||||||||||||
| 関連名称 | 10.3390/ph16030383 | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Curcumin and Andrographis Exhibit Anti-Tumor Effects in Colorectal Cancer via Activation of Ferroptosis and Dual Suppression of Glutathione Peroxidase-4 and Ferroptosis Suppressor Protein-1 | |||||||||||||||||||||
| 著者 |
宮崎, 克己
× 宮崎, 克己
WEKO
1391
× Xu, Caiming
× 島田, 光生
WEKO
1253
× Goel, Ajay
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| 抄録 | ||||||||||||||||||||||
| 内容記述 | Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. The limitations of current chemotherapeutic drugs in CRC include their toxicity, side effects, and exorbitant costs. To assess these unmet needs in CRC treatment, several naturally occurring compounds, including curcumin and andrographis, have gained increasing attention due to their multi-targeted functionality and safety vs. conventional drugs. In the current study, we revealed that a combination of curcumin and andrographis exhibited superior anti-tumor effects by inhibiting cell proliferation, invasion, colony formation, and inducing apoptosis. Genome-wide transcriptomic expression profiling analysis revealed that curcumin and andrographis activated the ferroptosis pathway. Moreover, we confirmed the gene and protein expression of glutathione peroxidase 4 (GPX-4) and ferroptosis suppressor protein 1 (FSP-1), the two major negative regulators of ferroptosis, were downregulated by this combined treatment. With this regimen, we also observed that intracellular accumulation of reactive oxygen species and lipid peroxides were induced in CRC cells. These cell line findings were validated in patient-derived organoids. In conclusion, our study revealed that combined treatment with curcumin and andrographis exhibited anti-tumorigenic effects in CRC cells through activation of ferroptosis and by dual suppression of GPX-4 and FSP-1, which have significant potential implications for the adjunctive treatment of CRC patients. | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | curcumin | |||||||||||||||||||||
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| 主題 | andrographis | |||||||||||||||||||||
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| 主題 | glutathione peroxidase 4 | |||||||||||||||||||||
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| 主題 | ferroptosis suppressor protein 1 | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | natural products | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | colorectal cancer | |||||||||||||||||||||
| 書誌情報 |
en : Pharmaceuticals 巻 16, 号 3, p. 383, 発行日 2023-03-02 |
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| 収録物ID | ||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 14248247 | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||
| 権利情報 | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||
| EID | ||||||||||||||||||||||
| 識別子 | 405956 | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
