| Item type |
文献 / Documents(1) |
| 公開日 |
2024-07-31 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1038/s41598-024-66823-2 |
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|
関連名称 |
10.1038/s41598-024-66823-2 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Quantitative evaluation of 67Ga-citrate scintigraphy in the management of nephritis |
| 著者 |
マツダ, ノリタケ
大塚, 秀樹
笠井, 亮佑
大谷, 環樹
Bollos, Leah Anne Christine Locsin
阿實, 翔太
国金, 大和
音見, 暢一
ウエキ, ユウヤ
オカベ, マナ
天野, 雅史
田蒔, 昌憲
𦚰野, 修
髙尾, 正一郎
原田, 雅史
|
| 抄録 |
|
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内容記述 |
In 67Ga-citrate scintigraphy (Ga-S), visual assessment is used by evaluating renal-uptake comparison with liver and spine and is simple and objective. We adopted the standardized uptake value (SUV) for 67Ga-citrate and proposed two quantitative indices, active nephritis volume (ANV) and total nephritis uptake (TNU). This study clarified the utility of new Ga-S-based quantitative indices in nephritis management. Before SUV measurement, the Becquerel calibration factor of 67Ga-citrate was obtained using a phantom experiment. Seventy patients who underwent SPECT/CT imaging were studied. SUV, ANV, and TNU were calculated using a quantitative analysis software for bone SPECT. SUVmean, ANV, and TNU were analyzed using the (1) threshold method (set 40%) and constant-value method for (2) vertebral SUVmax, and (3) vertebral SUVmean. ROC analysis was used to evaluate SUV, ANV, and TNU diagnostic abilities to distinguish nephritis presence and absence as well as interstitial nephritis (IN) and non-IN. The area under the curve (AUC) for nephritis presence or absence had a good value (0.80) for SUVmean (1), ANV (3), and TNU (3). The AUC for differentiation between IN and non-IN groups had a good value (0.80) for SUVmean (1). Thus, the new Ga-S-based quantitative indices were useful to evaluate nephritis and distinguish IN and non-IN. |
| キーワード |
|
|
主題 |
67Ga-citrate scintigraphy |
| キーワード |
|
|
主題 |
Interstitial nephritis |
| キーワード |
|
|
主題 |
Standardized uptake value |
| キーワード |
|
|
主題 |
Active nephritis volume |
| キーワード |
|
|
主題 |
Total nephritis uptake |
| 書誌情報 |
en : Scientific Reports
巻 14,
p. 16313,
発行日 2024-07-15
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20452322 |
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利情報 |
|
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
|
|
識別子 |
409256 |
| 言語 |
|
|
言語 |
eng |
srep_14_16313.pdf (2.67 MB)
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