| Item type |
文献 / Documents(1) |
| 公開日 |
2024-07-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1155/2023/7000858 |
|
|
関連名称 |
10.1155/2023/7000858 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Mosaic TP53 Mutation on Tumour Development in Pigs : A Case Study |
| 著者 |
ソンキテイデイロ, チヨンマナート
| ja |
ソンキテイデイロ, チヨンマナート
|
| ja-Kana |
トンキッチィディロク, チヨンマナート
|
| en |
Thongkittidilok, Chommanart
|
Search repository
平田, 真樹
Lin, Qingyi
トリゴエ, ナナカ
Liu, Bin
サトウ, ヨウコ
長原, 恵
谷原, 史倫
音井, 威重
|
| 抄録 |
|
|
内容記述 |
Pigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 sequence in tumorigenesis and to speculate how amino acid changes in TP53 sequences are related to tumorigenesis. The pig without tumours had a wild-type TP53 sequence and a 1-bp deletion in the TP53 sequence that resulted in a premature stop codon. In contrast, the pig with nephroblastoma had 6- and 7-bp deletions in the TP53 sequence, resulting in the absence of two amino acids and a premature stop codon, respectively. Our results indicated that TP53 mutations with truncated amino acids may be related to tumour formation. |
| 書誌情報 |
en : Veterinary Medicine International
巻 2023,
p. 7000858,
発行日 2023-08-14
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20908113 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20420048 |
| 出版者 |
|
|
出版者 |
Hindawi |
| 権利情報 |
|
|
権利情報 |
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
402890 |
| 言語 |
|
|
言語 |
eng |
vmi_2023_7000858.pdf (1.71 MB)
.png)
