| Item type |
文献 / Documents(1) |
| 公開日 |
2024-08-16 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1007/s10157-024-02502-w |
|
|
関連名称 |
10.1007/s10157-024-02502-w |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Ability of NAD and Sirt1 to epigenetically suppress albuminuria |
| 著者 |
長谷川, 一宏
田蒔, 昌憲
柴田, 恵理子
稲垣, 太造
湊, 将典
ヤマグチ, スミヨ
シミズ, イクコ
ミヤカミ, シンジ
タダ, ミホ
𦚰野, 修
|
| 抄録 |
|
|
内容記述 |
The time for diabetic nephropathy (DN) to progress from mild to severe is long. Thus, methods to continuously repress DN are required to exert long-lasting effects mediated through epigenetic regulation. In this study, we demonstrated the ability of nicotinamide adenine dinucleotide (NAD) and its metabolites to reduce albuminuria through Sirt1- or Nampt-dependent epigenetic regulation. We previously reported that proximal tubular Sirt1 was lowered before glomerular Sirt1. Repressed glomerular Sirt1 was found to epigenetically elevate Claudin-1. In addition, we reported that proximal tubular Nampt deficiency epigenetically augmented TIMP-1 levels in Sirt6-mediated pathways, leading to type-IV collagen deposition and diabetic fibrosis. Altogether, we propose that the Sirt1/Claudin-1 axis may be crucial in the onset of albuminuria at the early stages of DN and that the Nampt/Sirt6/TIMP-1 axis promotes diabetic fibrosis in the middle to late stages of DN. Finally, administration of NMN, an NAD precursor, epigenetically potentiates the regression of the onset of DN to maintain Sirt1 and repress Claudin-1 in podocytes, suggesting the potential use of NAD metabolites as epigenetic medications for DN. |
| キーワード |
|
|
主題 |
Sirtuin 1 |
| キーワード |
|
|
主題 |
Nicotinamide mononucleotide |
| キーワード |
|
|
主題 |
Claudin-1 |
| 書誌情報 |
en : Clinical and Experimental Nephrology
巻 28,
号 7,
p. 599-607,
発行日 2024-04-08
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13421751 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14377799 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11126935 |
| 出版者 |
|
|
出版者 |
Japanese Society of Nephrology |
| 出版者 |
|
|
出版者 |
Springer |
| 権利情報 |
|
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| EID |
|
|
識別子 |
410122 |
| 言語 |
|
|
言語 |
eng |
cen_28_7_599.pdf (2.27 MB)
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