| Item type |
文献 / Documents(1) |
| 公開日 |
2024-08-28 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1210/clinem/dgae124 |
|
|
関連名称 |
10.1210/clinem/dgae124 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Prospective Multicenter Registry-Based Study on Thyroid Storm : The Guidelines for Management From Japan Are Useful |
| 著者 |
フルカワ, ヤスシ
タナカ, ケイコ
イソザキ, オサム
スズキ, アツシ
イブリ, タダオ
ツボイ, クミコ
イグチ, モリタケ
カナモト, ナオテツ
ミナミタニ, カンシ
𦚰野, 修
サトウ, テツロウ
テラムカイ, サトシ
キムラ, エイゼン
ミヤケ, ヨシヒロ
アカミズ, タカシ
|
| 抄録 |
|
|
内容記述 |
Context: The mortality rate in thyroid storm (TS) has been reported to be higher than 10%.
Objective: We aimed to evaluate the effectiveness of the 2016 guidelines for the management of TS proposed by the Japan Thyroid Association and Japan Endocrine Society.
Methods: In this prospective multicenter registry–based study, patients with new-onset TS were registered in the Research Electronic Data Capture (REDCap), a secure web platform. On day 30 after admission, clinical information and prognosis of each patient were added to the platform. On day 180, the prognosis was described.
Results: This study included 110 patients with TS. The median of Acute Physiology and Chronic Health Evaluation (APACHE) II score was 13, higher than the score (10) in the previous nationwide epidemiological study (P = .001). Nonetheless, the mortality rate at day 30 was 5.5%, approximately half compared with 10.7% in the previous nationwide survey. Lower body mass index, shock, and lower left ventricular ejection fraction were positively associated with poor prognosis at day 30, while the lack of fever ≥ 38 °C was related to the outcome. The mortality rate in patients with an APACHE II score ≥ 12 for whom the guidelines were not followed was significantly higher than the rate in patients for whom the guidelines were followed (50% vs 4.7%) (P = .01).
Conclusion: Prognosis seemed better than in the previous nationwide survey, even though disease severity was higher. The mortality rate was lower when the guidelines were followed. Thus, the guidelines are useful for managing TS. |
| キーワード |
|
|
主題 |
epidemiology |
| キーワード |
|
|
主題 |
prospective |
| キーワード |
|
|
主題 |
REDCap |
| キーワード |
|
|
主題 |
thyroid crisis |
| キーワード |
|
|
主題 |
Graves disease |
| キーワード |
|
|
主題 |
thyrotoxicosis |
| 書誌情報 |
en : The Journal of Clinical Endocrinology & Metabolism
p. dgae124,
発行日 2024-03-08
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19457197 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0021972X |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00695484 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1203774X |
| 出版者 |
|
|
出版者 |
The Endocrine Society |
| 出版者 |
|
|
出版者 |
Oxford University Press |
| 権利情報 |
|
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. |
| EID |
|
|
識別子 |
411330 |
| 言語 |
|
|
言語 |
eng |
jcem_dgae124.pdf (595 KB)
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