| Item type |
文献 / Documents(1) |
| 公開日 |
2024-12-11 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1039/D4CC02199A |
|
|
関連名称 |
10.1039/D4CC02199A |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Total synthesis of 1,4a-di-epi-ent-pancratistatin, exemplifying a stereodivergent approach to pancratistatin isomers |
| 著者 |
Sun, Chunzhao
猪熊, 翼
辻, 大輔
ヤマオカ, ヨウスケ
アカギ, レイコ
山田, 健一
|
| 抄録 |
|
|
内容記述 |
The total synthesis of 1,4a-di-epi-ent-pancratistatin, a novel stereoisomer of the anti-tumor Amaryllidaceae alkaloid pancratistatin, was achieved in 14 steps starting from D-mannitol. The construction of the pancratistatin skeleton involved conjugate addition of organocuprate to a nitrosoolefin, which was generated in situ from inosose oxime. This was followed by stereoselective reduction of the oxime to an amine and site-selective formylation. Biological evaluations revealed that the newly synthesized compounds exhibit cytotoxicity toward cancer cells and significant ferroptosis inhibitory activity. These compounds constitute a promising small-molecule library for the development of potent bioactive agents. |
| 書誌情報 |
en : Chemical Communications
巻 60,
号 53,
p. 6757-6760,
発行日 2024-06-06
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1364548X |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11071130 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12455105 |
| 出版者 |
|
|
出版者 |
The Royal Society of Chemistry |
| EID |
|
|
識別子 |
408859 |
| 言語 |
|
|
言語 |
eng |
chemcom_60_53_6757.pdf (1.21 MB)
