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Intradermal delivery of a liposomal formulation encapsulating amphiphilic ascorbic acid by iontophoresis for promotion of collagen synthesis
https://tokushima-u.repo.nii.ac.jp/records/2012351
https://tokushima-u.repo.nii.ac.jp/records/2012351c11a6a96-376e-4faa-b5f5-d1907a4d77b6
| 名前 / ファイル | ライセンス | アクション |
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jddst_103_106438.pdf (1.02 MB)
Download is available from 2025/11/24.
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2024-12-13 | |||||||||||||||||||||||
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| アクセス権 | embargoed access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | NA | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Intradermal delivery of a liposomal formulation encapsulating amphiphilic ascorbic acid by iontophoresis for promotion of collagen synthesis | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 著者 |
ヨシダ, ヒビキ
× ヨシダ, ヒビキ
× ヤマグチ, リオ
× 米田, 晋太朗
× 山﨑, 尚志× 小暮, 健太朗 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Collagen is a structural protein in skin that is an important component for maintaining skin functions, such as elasticity. As the amount and functional capacity of collagen in the skin decreases with age, wrinkles and skin sagging are induced. Treatment of the skin with vitamin C (ascorbic acid, AsA) is attracting attention as a means of inducing collagen production. However, penetration of AsA into the skin is difficult due to its hydrophilicity. To overcome this limitation, we focused on a combination of iontophoresis (ItP), which is a non-invasive intradermal drug delivery technology, and use of a liposome formulation, to improve skin penetration of AsA. In this study, palmitoylated AsA was used to increase the encapsulation efficiency into liposomes. We prepared liposomes encapsulating palmitoylated AsA (AsA-lipo) and performed ItP of fluorescently-labeled AsA-lipo on the shaved dorsal skin of rats. Fluorescence of the liposomes was observed in skin sections following ItP, indicating that AsA-lipo was delivered into the skin. The amount of collagen in the skin after ItP of AsA-lipo increased with the number of doses, and the amount of collagen mRNA also showed an increasing trend. Furthermore, the amount of hydroxyproline, which is a major component of collagen, was significantly increased in skin treated with AsA-lipo via ItP. In conclusion, results of this study demonstrate the successful promotion of skin collagen synthesis by non-invasive iontophoretic intradermal delivery of AsA-lipo. | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Iontophoresis | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Intradermal delivery | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Ascorbic acid|Liposomes | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Collagen synthesis | |||||||||||||||||||||||
| 書誌情報 |
en : Journal of Drug Delivery Science and Technology 巻 103, p. 106438, 発行日 2024-11-24 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 25888943 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 17732247 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 言語 | ja | |||||||||||||||||||||||
| 値 | 論文本文は2025-11-24以降公開予定 | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 権利情報 | © 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||
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| 識別子 | 415257 | |||||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
