WEKO3
アイテム
Frequency-dependent characteristics of osteoblast calcium signaling responses to microvibrational stimulation
https://tokushima-u.repo.nii.ac.jp/records/2012392
https://tokushima-u.repo.nii.ac.jp/records/201239224ee126e-ff35-41f0-9654-eb07148104f3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jbr_38_2_55.pdf (3.8 MB)
|
.png)
|
| Item type | 文献 / Documents(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-01-31 | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 出版社版DOI | ||||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.17106/jbr.38.55 | |||||||||||||
| 言語 | ja | |||||||||||||
| 関連名称 | 10.17106/jbr.38.55 | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Frequency-dependent characteristics of osteoblast calcium signaling responses to microvibrational stimulation | |||||||||||||
| 言語 | en | |||||||||||||
| 著者 |
佐藤, 克也
× 佐藤, 克也
WEKO
367
× Eihara, Taira
|
|||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | The metabolism of bone tissue is regulated by mechanical stimuli. It has been reported that low-intensity, high-frequency vibratory stimuli can activate bone tissue metabolism. Identifying effective vibration conditions that enhance bone formation could potentially be exploited to prevent the onset and progression of osteoporosis, thereby improving quality of life in an aging society. Experiments using model animals have investigated the effects of various frequencies of vibratory stimuli, but there remains no consensus on the most effective frequency. In this study, we used a simple cell culture system to evaluate the calcium signaling response of osteoblasts subjected to micro-vibratory stimuli at different frequencies. Using a custom-developed vibration device, we applied vibratory stimuli to osteoblasts under microscopic observation and evaluated the calcium signaling response using a fluorescent calcium indicator. The vibratory stimuli were applied from 45 to 120 Hz in 15 Hz increments and from 120 to 45 Hz in 15 Hz decrements. The results of the experiment showed that the highest response rate was obtained at 60 Hz in the 45 to 120 Hz group, and at 105 Hz in the 120 to 45 Hz group. These results suggest that in an experimental system where the frequency is swept, the cells respond at the beginning of stimulation, and that habituation may contribute significantly thereafter. | |||||||||||||
| 言語 | en | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | osteoblast | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | mechanical vibration | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | bone metabolism | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | mechanotransduction | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | biomechanics | |||||||||||||
| 書誌情報 |
en : Journal of Biorheology 巻 38, 号 2, p. 55-64, 発行日 2024 |
|||||||||||||
| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 18670466 | |||||||||||||
| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 18670474 | |||||||||||||
| 収録物ID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA12499756 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Japanese Society of Biorheology | |||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | This article is licensed under a Creative Commons [Attribution 4.0 International] license. https://creativecommons.org/licenses/by/4.0/ | |||||||||||||
| EID | ||||||||||||||
| 識別子 | 415775 | |||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
