| Item type |
文献 / Documents(1) |
| 公開日 |
2025-02-14 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.neuint.2024.105863 |
|
|
関連名称 |
10.1016/j.neuint.2024.105863 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Statins ameliorate oxaliplatin- and paclitaxel-induced peripheral neuropathy via glutathione S-transferase |
| 著者 |
相澤, 風花
Kajimoto, Haruna
Okabayashi, Ami
Moriyama, Daishi
八木, 健太
Takahashi, Shimon
Sonoda, Yuhei
Shibata, Takahiro
合田, 光寛
新村, 貴博
(井澤)石澤, 有紀
濱野, 裕章
川田, 敬
座間味, 義人
石澤, 啓介
|
| 抄録 |
|
|
内容記述 |
Some therapeutic agents have been found to have effects beyond their primary indications. Peripheral neuropathy, a common side effect of chemotherapy, remains inadequately treated. Identifying additional properties of existing medications could thus uncover novel therapeutic avenues. Previous studies have identified an additional effect of simvastatin in reducing neuropathy; however, the mechanism underlying this effect remains unclear. We investigated the novel effects of statins on chemotherapy-induced peripheral neuropathy in mice. Mice treated with oxaliplatin or paclitaxel did not show exacerbation or improvement in cold sensations upon acetone testing with statin administration. However, concurrent oral statin treatment mitigated the nociceptive response to mechanical stimuli induced by each anti-tumor agent. Co-administration of a glutathione S-transferase inhibitor, which modulates redox reactions, abolished the ameliorative effect of statins on mechanical nociceptive behavior. Additionally, the glutathione S-transferase inhibitor did not affect normal sensory perception or impair the anti-tumor effect of chemotherapy agents. A search for GST-associated molecules and pathways using artificial intelligence revealed that GST regulates inflammatory cytokines as a regulatory or causative gene. Our findings suggest that statins have class effects that ameliorate cytotoxic anti-cancer drug-induced mechanical allodynia via GST pathway activation. |
| キーワード |
|
|
主題 |
Drug repositioning |
| キーワード |
|
|
主題 |
HMG-CoA reductase inhibitor |
| キーワード |
|
|
主題 |
Neuropathy |
| キーワード |
|
|
主題 |
Oxaliplatin |
| キーワード |
|
|
主題 |
Paclitaxel |
| キーワード |
|
|
主題 |
Supportive care |
| 書誌情報 |
en : Neurochemistry International
巻 180,
p. 105863,
発行日 2024-09-21
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
18729754 |
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
01970186 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11540402 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0032399X |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
415126 |
| 言語 |
|
|
言語 |
eng |
neuint_180_105863.pdf (1.7 MB)
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