| Item type |
文献 / Documents(1) |
| 公開日 |
2025-02-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.57444/shikokuactamedica.80.3.4_121 |
|
|
関連名称 |
10.57444/shikokuactamedica.80.3.4_121 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
アベマシクリブ投与中に重篤な間質性肺疾患をきたしたが救命しえた1例 |
| タイトル別表記 |
|
|
その他のタイトル |
A case of severe interstitial lung disease developed during administration of abemaciclib but successfully rescued |
| 著者 |
乾, 友浩
井上, 寛章
磯村, 祐太
行重, 佐和香
宮本, 直輝
笹, 聡一郎
(青山)三崎, 万理子
後藤, 正和
鳥羽, 博明
滝沢, 宏光
|
| 抄録 |
|
|
内容記述 |
Abemaciclib, Selective cyclin-dependent kinase 4 and 6 inhibitor has become available for use in hormone receptor-positive and HER2 - negative unresectable or recurrent breast cancer, significantly extending progression-free survival and improving prognosis. However, caution is necessary as in some cases it may cause drug-induced interstitial lung disease, occasionally leading to severe exacerbations. The case involves a 75-year-old female who was emergency transported to our hospital due to dyspnea occurring 11 months after initiating abemaciclib + letrozole therapy for hormone receptor-positive, HER2 - negative recurrent breast cancer. Upon arrival, she presented with typeⅠrespiratory failure with PCO2 : 24.5 mmHg, PO2 : 61.2 mmHg, and CT revealing ground-glass opacities in both lung fields. Diagnosed with drug-induced interstitial lung disease, she underwent endotracheal intubation followed by steroid pulse therapy. After three rounds of steroid pulses, symptoms gradually improved, allowing for discharge home with oxygen supplementation. Despite the development of severe interstitial lung disease in this case, prompt initiation of treatment facilitated successful life-saving intervention. |
| キーワード |
|
|
主題 |
abemaciclib |
| キーワード |
|
|
主題 |
cyclin-dependent kinase 4 and 6 inhibitor |
| キーワード |
|
|
主題 |
breast cancer |
| キーワード |
|
|
主題 |
interstitial lung disease |
| 書誌情報 |
ja : 四国医学雑誌
en : Shikoku Acta Medica
巻 80,
号 3-4,
p. 121-124,
発行日 2024-10-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
27583279 |
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
00373699 |
| 出版者 |
|
|
出版者 |
徳島医学会 |
| EID |
|
|
識別子 |
415987 |
| 言語 |
|
|
言語 |
jpn |
sam_80_3-4_121.pdf (952 KB)
