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Effect of interleukin-17A on inflammatory mediator production in interleukin-1β-stimulated human dental pulp fibroblasts
https://tokushima-u.repo.nii.ac.jp/records/2012489
https://tokushima-u.repo.nii.ac.jp/records/2012489eb2bd2c8-9f2e-42eb-b48d-7c59a502c0dc
| 名前 / ファイル | ライセンス | アクション |
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eos_132_5_e13019.pdf (902 KB)
Download is available from 2025/9/20.
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2025-02-26 | |||||||||||||||||||||
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| アクセス権 | embargoed access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1111/eos.13019 | |||||||||||||||||||||
| 関連名称 | 10.1111/eos.13019 | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Effect of interleukin-17A on inflammatory mediator production in interleukin-1β-stimulated human dental pulp fibroblasts | |||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||
| その他のタイトル | Effect of IL-17A on dental pulp cells | |||||||||||||||||||||
| 著者 |
中西, 正
× 中西, 正
WEKO
1704
× Mieda, Katsuhiro
× Kuramoto, Hitomi
× 武川, 大輔
WEKO
566
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| 内容記述 | In response to pro-inflammatory cytokines such as interleukin (IL)-1β, dental pulp fibroblasts produce various inflammatory mediators, including IL-6, IL-8, CC chemokine ligand 20 (CCL20) and CXC chemokine ligand 10 (CXCL10), leading to the progression of pulpitis. IL-17/IL-17A (IL-17A) is a pro-inflammatory cytokine secreted by T helper (Th) 17 cells following their recruitment to inflamed sites; however, the roles of IL-17A during pulpitis remain unclear. The purpose of this study was to investigate the effect of IL-17A on IL-6, IL-8, CCL20 and CXCL10 production by human dental pulp fibroblasts (HDPFs) in vitro. IL-17A at a concentration of 100 ng/ml induced the production of 10 times more IL-8 and 4 times more CXCL10, but not IL-6 and CCL20, compared to controls. Co-stimulation of HDPFs with IL-17A and IL-1β synergistically enhanced the production of IL-6, CCL20, IL-8 and CXCL10. IL-1β increased expression of IL-17 receptor/IL-17RA (IL-17R) on HDPFs. Moreover, the cell signal pathways of p38 mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) were more potently activated by simultaneous stimulation with IL-17A and IL-1β. These findings suggest that IL-17A participates in the progression of dental pulp inflammation through the enhanced production of inflammatory mediators in HDPFs. | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | chemokines | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | cytokines | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | endodontics | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | pulpitis | |||||||||||||||||||||
| 書誌情報 |
en : European Journal of Oral Sciences 巻 132, 号 5, p. e13019, 発行日 2024-09-20 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 16000722 | |||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 09098836 | |||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA11623000 | |||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA11033550 | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | John Wiley & Sons Ltd | |||||||||||||||||||||
| 備考 | ||||||||||||||||||||||
| 値 | This is the peer reviewed version of the following article: Nakanishi, T., Mieda, K., Kuramoto, H., Takegawa, D. (2024), Effect of interleukin-17A on inflammatory mediator production in interleukin-1β-stimulated human dental pulp fibroblasts. European Journal of Oral Sciences, 132, 5, e13019., which has been published in final form at https://doi.org/10.1111/eos.13019. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | |||||||||||||||||||||
| EID | ||||||||||||||||||||||
| 識別子 | 416188 | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
