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Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
https://tokushima-u.repo.nii.ac.jp/records/2012620
https://tokushima-u.repo.nii.ac.jp/records/201262098c1abaf-c3da-449f-994d-9fa969204f6a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jem_207_5_963.pdf (2.3 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||
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| 公開日 | 2025-03-05 | |||||||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1084/jem.20092144 | |||||||||||||||||||||||||||||||
| 関連名称 | 10.1084/jem.20092144 | |||||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||
| タイトル | Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation | |||||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||||
| その他のタイトル | Fate mapping of Aire-expressing cells | |||||||||||||||||||||||||||||||
| 著者 |
西川, 裕美子
× 西川, 裕美子× Hirota, Fumiko
× 矢野, 雅司
WEKO
1278
× Kitajima, Hiroyuki
× Miyazaki, Jun-ichi
× Kawamoto, Hiroshi
× 毛利, 安宏
WEKO
1273
× 松本, 満
WEKO
1118
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| 抄録 | ||||||||||||||||||||||||||||||||
| 内容記述 | The roles of autoimmune regulator (Aire)–expressing medullary thymic epithelial cells (mTECs) in the organization of the thymic microenvironment for establishing self-tolerance are enigmatic. We sought to monitor the production and maintenance of Aire-expressing mTECs by a fate-mapping strategy in which bacterial artificial chromosome transgenic (Tg) mice expressing Cre recombinase under the control of the Aire regulatory element were crossed with a GFP reporter strain. We found that, in addition to its well recognized expression within mature mTECs, Aire was expressed in the early embryo before emergence of the three germ cell layers. This observation may help to explain the development of ectodermal dystrophy often seen in patients with AIRE deficiency. With the use of one Tg line in which Cre recombinase expression was confined to mTECs, we found that Aire+CD80high mTECs further progressed to an Aire−CD80intermediate stage, suggesting that Aire expression is not constitutive from after its induction until cell death but instead is down-regulated at the beginning of terminal differentiation. We also demonstrated that many mTECs of Aire-expressing lineage are in close contact with thymic dendritic cells. This close proximity may contribute to transfer of tissue-restricted self-antigens expressed by mTECs to professional antigen-presenting cells. | |||||||||||||||||||||||||||||||
| 書誌情報 |
en : Journal of Experimental Medicine 巻 207, 号 5, p. 963-971, 発行日 2010-04-19 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||||||
| 収録物識別子 | 15409538 | |||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||||||||||
| 収録物識別子 | 00221007 | |||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||||
| 収録物識別子 | AA12119243 | |||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||||||||
| 収録物識別子 | AA00697559 | |||||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||||
| 出版者 | Rockefeller University Press | |||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||
| 権利情報 | © 2010 Nishikawa et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). | |||||||||||||||||||||||||||||||
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| 識別子 | 264729 | |||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||
