| Item type |
文献 / Documents(1) |
| 公開日 |
2025-03-25 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/biomedicines12081789 |
|
|
関連名称 |
10.3390/biomedicines12081789 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Development of Liver Fibrosis Represented by the Fibrosis-4 Index Is a Specific Risk Factor for Tubular Injury in Individuals with Type 2 Diabetes |
| 著者 |
原, 倫世
渡邊, 毅
山上, 紘規
Miyataka, Kohsuke
Yasui, Saya
Asai, Takahito
Kaneko, Yousuke
Mitsui, Yukari
Masuda, Shiho
倉橋, 清衛
Otoda, Toshiki
湯浅, 智之
黒田, 暁生
遠藤, 逸朗
Honda, Soichi
Kondo, Akira
松久, 宗英
粟飯原, 賢一
|
| 抄録 |
|
|
内容記述 |
Although hyperglycemia and hypertension are well-known risk factors for glomerular injury in individuals with type 2 diabetes (T2D), specific risk factors for tubular injury remain unclear. We aimed to clarify the differences between risk factors for glomerular injury and risk factors for tubular injury in individuals with T2D. We categorized 1243 subjects into four groups based on urinary biomarkers, including the albumin-to-creatinine ratio (uACR) and L-type fatty acid-binding protein-to-creatinine ratio (uL-ABPCR) as a normal (N) group (uACR < 30 mg/gCr and uL-FABPCR < 5 μg/gCr; n = 637), a glomerular specific injury (G) group (uACR ≥ 30 mg/gCr and uL-FABPCR < 5 μg/gCr; n = 248), a tubular specific injury (T) group (uACR < 30 mg/gCr and uL-FABPCR ≥ 5 μg/gCr; n = 90), and a dual injury (D) group (uACR ≥ 30 mg/gCr and uL-FABPCR ≥ 5 μg/gCr; n = 268). Logistic regression analysis referencing the N group revealed that BMI, current smoking, and hypertension were risk factors for the G group, creatinine (Cr) and Fibrosis-4 (FIB-4) index were risk factors for the T group, and BMI, hypertension, HbA1c, Cr, and duration of diabetes were risk factors for the D group. While hypertension was a distinct specific risk factor for glomerular injury, the FIB-4 index was a specific contributor to the prevalence of tubular injury. On the other hand, the logistic regression analysis revealed that the hepatic steatosis index (HSI) did not show any significant association with the G group, T group, or D group. Taken together, the development of liver fibrosis rather than liver steatosis is an inherent threat relating to tubular injury in individuals with T2D. |
| キーワード |
|
|
主題 |
Fibrosis-4 index |
| キーワード |
|
|
主題 |
liver fibrosis |
| キーワード |
|
|
主題 |
type 2 diabetes |
| キーワード |
|
|
主題 |
diabetic kidney disease |
| キーワード |
|
|
主題 |
tubular injury |
| キーワード |
|
|
主題 |
L-FABP |
| 書誌情報 |
en : Biomedicines
巻 12,
号 8,
p. 1789,
発行日 2024-08-07
|
| 収録物ID |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
22279059 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
411497 |
| 言語 |
|
|
言語 |
eng |
biomed_12_8_1789.pdf (1.2 MB)
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