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Flavonoids, nobiletin, heptamethoxyflavone, and genistein enhance antigen-presenting cell function in vitro
https://tokushima-u.repo.nii.ac.jp/records/2012786
https://tokushima-u.repo.nii.ac.jp/records/20127868d28acd1-31f4-4ee3-b170-d717af7e5d3c
| 名前 / ファイル | ライセンス | アクション |
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eoi_4_333.pdf (983 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||
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| 公開日 | 2025-03-26 | |||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.37349/ei.2024.00144 | |||||||||||||||||||||||||||
| 関連名称 | 10.37349/ei.2024.00144 | |||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||
| タイトル | Flavonoids, nobiletin, heptamethoxyflavone, and genistein enhance antigen-presenting cell function in vitro | |||||||||||||||||||||||||||
| 著者 |
Tanaka, Yuko
× Tanaka, Yuko
× 中本, 晶子
WEKO
863
× Ohashi, Haruka
× 中本, 真理子
WEKO
782
× 酒井, 徹
WEKO
1196
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| 内容記述 | Aim: Antigen (Ag) presentation by Ag-presenting cells (APCs) is the first step in the generation of adaptive humoral and cellular immune responses. However, there have been few studies on the effects of flavonoids on APC function. In this study, we examined the effects of five polymethoxyflavones, two isoflavones, and one flavanol on CD11c+dendritic cell function. Methods: CD11c+dendritic cells were differentiated from bone marrow cells by culturing with granulocyte macrophage-colony stimulating factor. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay. The Ag-presenting ability was determined by a mixed lymphocyte reaction assay. Expressions of MHC class II, CD40, CD80, and CD86 molecules on CD11c+cells were determined by flow cytometric analysis. Lipopolysaccharide-induced inflammatory cytokines productions were determined by enzyme-linked immunosorbent assay. Results: The flavonoids used in the study did not show strong toxicity to CD11c+cells. Nobiletin, heptamethoxyflavone, and genistein enhance Ag-presenting function. Nobiletin and heptamethoxyflavone increased the expression of MHC class II and CD80 molecules. A direct correlation between APC function and lipopolysaccharide-induced cytokine production was not found. Conclusions: The results of the in vitro study indicate that flavonoids, nobiletin, heptamethoxyflavone, and genistein regulate innate dendritic cell function. |
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| キーワード | ||||||||||||||||||||||||||||
| 主題 | Antigen-presenting cells | |||||||||||||||||||||||||||
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| 主題 | citrus flavonoids | |||||||||||||||||||||||||||
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| 主題 | nobiletin | |||||||||||||||||||||||||||
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| 主題 | heptamethoxyflavone | |||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||
| 主題 | genistein | |||||||||||||||||||||||||||
| 書誌情報 |
en : Exploration of Immunology 巻 4, p. 333-340, 発行日 2024-05-29 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 27686655 | |||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||
| 出版者 | Open Exploration | |||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||
| 権利情報 | This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |||||||||||||||||||||||||||
| EID | ||||||||||||||||||||||||||||
| 識別子 | 410328 | |||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||
