| Item type |
文献 / Documents(1) |
| 公開日 |
2025-03-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/biom14040444 |
|
|
関連名称 |
10.3390/biom14040444 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Emerging Insights into the Role of BDNF on Health and Disease in Periphery |
| 著者 |
(市村)清水, 真祐子
Kurrey, Khuleshwari
Miyata, Misaki
Dezawa, Takuya
常山, 幸一
Kojima, Masami
|
| 抄録 |
|
|
内容記述 |
Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain. However, reduced BDNF expression and single nucleotide polymorphisms (SNP) are reported to be associated with functional deficit and disease development in the brain, suggesting that BDNF is a crucial molecule for brain health. Interestingly, BDNF is also expressed in the hypothalamus in appetite and energy metabolism. Previous reports demonstrated that BDNF knockout mice exhibited overeating and obesity phenotypes remarkably. Therefore, we could raise a hypothesis that the loss of function of BDNF may be associated with metabolic syndrome and peripheral diseases. In this review, we describe our recent finding that BDNF knockout mice develop metabolic dysfunction-associated steatohepatitis and recent reports demonstrating the role of one of the BDNF receptors, TrkB-T1, in some peripheral organ functions and diseases, and would provide an insight into the role of BDNF beyond the brain. |
| キーワード |
|
|
主題 |
brain-derived neurotrophic factor |
| キーワード |
|
|
主題 |
steatohepatitis |
| キーワード |
|
|
主題 |
MASH |
| キーワード |
|
|
主題 |
MASLD |
| キーワード |
|
|
主題 |
metabolic syndrome |
| キーワード |
|
|
主題 |
hyperphagia |
| キーワード |
|
|
主題 |
inflammation |
| キーワード |
|
|
主題 |
fibrosis |
| キーワード |
|
|
主題 |
animal model |
| 書誌情報 |
en : Biomolecules
巻 14,
号 4,
p. 444,
発行日 2024-04-05
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2218273X |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
410682 |
| 言語 |
|
|
言語 |
eng |
biom_14_4_444.pdf (1 MB)
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