| Item type |
文献 / Documents(1) |
| 公開日 |
2025-03-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.jphs.2024.08.002 |
|
|
関連名称 |
10.1016/j.jphs.2024.08.002 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effects of D-Allose on experimental cardiac hypertrophy |
| 著者 |
Akumwami, Steeve
Rahman, Asadur
船本, 雅文
Hossain, Akram
Morishita, Asahiro
池田, 康将
Kitamura, Hiroaki
Kitada, Kento
Noma, Takahisa
Ogino, Yuichi
Nishiyama, Akira
|
| 抄録 |
|
|
内容記述 |
The hallmark of pathological cardiac hypertrophy is the decline in myocardial contractility caused by an energy deficit resulting from metabolic abnormalities, particularly those related to glucose metabolism. Here, we aim to explore whether D-Allose, a rare sugar that utilizes the same transporters as glucose, may restore metabolic equilibrium and reverse cardiac hypertrophy. Isolated neonatal rat cardiomyocytes were stimulated with phenylephrine and treated with D-Allose simultaneously for 48 h. D-Allose treatment resulted in a pronounced reduction in cardiomyocyte size and cardiac remodelling markers accompanied with a dramatic reduction in the level of intracellular glucose in phenylephrine-stimulated cells. The metabolic flux analysis provided further insights revealing that D-Allose exerted a remarkable inhibition of glycolysis as well as glycolytic capacity. Furthermore, in mice subjected to a 14-day continuous infusion of isoproterenol (ISO) to induce cardiac hypertrophy, D-Allose treatment via drinking water notably reduced ISO-induced cardiac hypertrophy and remodelling markers, with minimal effects on ventricular wall thickness observed in echocardiographic analyses. These findings indicate that D-Allose has the ability to attenuate the progression of cardiomyocyte hypertrophy by decreasing intracellular glucose flux and inhibiting glycolysis. |
| キーワード |
|
|
主題 |
Cardiac hypertrophy |
| キーワード |
|
|
主題 |
D-Allose |
| キーワード |
|
|
主題 |
Glycolysis |
| キーワード |
|
|
主題 |
Mitochondrial function |
| 書誌情報 |
en : Journal of Pharmacological Sciences
巻 156,
号 2,
p. 142-148,
発行日 2024-08-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
13478648 |
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
13478613 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 出版者 |
|
|
出版者 |
Japanese Pharmacological Society |
| 権利情報 |
|
|
権利情報 |
This is an open access article under theCC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
414311 |
| 言語 |
|
|
言語 |
eng |
jphs_156_2_142.pdf (1.1 MB)
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