| Item type |
文献 / Documents(1) |
| 公開日 |
2024-10-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| item_1722929371688 |
|
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|
識別子タイプ |
DOI |
|
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関連識別子 |
https://doi.org/10.1371/journal.pone.0063542 |
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|
言語 |
ja |
|
|
関連名称 |
10.1371/journal.pone.0063542 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Singlet Oxygen Induced Products of Linoleates, 10- and 12-(Z,E)-Hydroxyoctadecadienoic Acids (HODE), Can Be Potential Biomarkers for Early Detection of Type 2 Diabetes |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
10- and 12-HODE as Biomarkers for Pre-Diabetes |
|
言語 |
en |
| 著者 |
Umeno, Aya
Shichiri, Mototada
Ishida, Noriko
Hashimoto, Yoshiko
阿部, 佳織
Kataoka, Masatoshi
Yoshino, Kohzoh
Hagihara, Yoshihisa
Aki, Nanako
船木, 真理
Asada, Yasuhiko
Yoshida, Yasukazu
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Current diagnostic tests such as glycemic indicators have limitations for early detection of impaired glucose tolerance (IGT), which leads to diabetes. Oxidative stress induced by various oxidants in a random and destructive manner is considered to play an important role in the pathophysiology of a number of human disorders and diseases such as impaired glucose tolerance. We have developed an improved method for the measurement of in vivo lipid peroxidation, where the presence of 8-iso-prostaglandin F2α (8-iso-PGF2α), hydroxyoctadecadienoic acids (HODEs), hydroxyeicosatetraenoic acids (HETEs), and 7-hydroxycholesterol (7-OHCh), as well as their parent molecules, linoleic acid (LA) and cholesterol (Ch), was determined by performing LC-MS/MS (for 8-iso-PGF2α, HODE, and HETE) and GC-MS (for 7-OHCh, LA, and Ch) after reduction with triphenyl phosphine and saponification by potassium hydroxide. We then applied this method to volunteers (n = 57), including normal type (n = 43), “high-normal” (fasting plasma glucose, 100–109 mg/dL, n = 7), pre-diabetic type (IGT, n = 5), and diabetic type (n = 2) subjects who are diagnosed by performing oral glucose tolerance tests (OGTTs). Several biomarkers in plasma, such as insulin, leptin, adiponectin, interleukin-6, tumor necrosis factor-α, high sensitivity-C-reactive protein, HbA1c, and glucose levels were measured during OGTT. We found that the fasting levels of (10- and 12-(Z,E)- HODE)/LA increased significantly with increasing levels of HbA1c and glucose during OGTT and with insulin secretion and resistance index. In conclusion, 10- and 12-(Z,E)-HODE may be prominent biomarkers for the early detection of IGT and “high-normal” type without OGTT. |
|
言語 |
en |
| bibliographic_information |
en : PLOS ONE
巻 8,
号 5,
p. e63542,
発行日 2013-05-15
|
| 収録物ID |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
|
言語 |
en |
| item_10001_rights_15 |
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|
言語 |
en |
|
権利情報 |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| item_1723180141928 |
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|
識別子 |
309815 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_8_5_e63542.pdf (922 KB)
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