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Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice
https://tokushima-u.repo.nii.ac.jp/records/2000233
https://tokushima-u.repo.nii.ac.jp/records/200023392b6bc51-82ce-4944-9dc8-d1d3d6225471
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
pone_5_12_e14391.pdf (469 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2024-10-11 | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0014391 | |||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0014391 | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Identification of the Transgenic Integration Site in Immunodeficient tgε26 Human CD3ε Transgenic Mice | |||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||
| その他のタイトル | Tgε26 Integration Site | |||||||||||||||||||||
| 著者 |
大東, いずみ
× 大東, いずみ
WEKO
424
× Yamasaki, Yuki
× Hirashima, Tsukasa
× 高浜, 洋介
WEKO
1519
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| 抄録 | ||||||||||||||||||||||
| 内容記述 | A strain of human CD3ε transgenic mice, tgε26, exhibits severe immunodeficiency associated with early arrest of T cell development. Complete loss of T cells is observed in homozygous tgε26 mice, but not in heterozygotes, suggesting that genomic disruption due to transgenic integration may contribute to the arrest of T cell development. Here we report the identification of the transgenic integration site in tgε26 mice. We found that multiple copies of the human CD3ε transgene are inserted between the Sstr5 and Metrn loci on chromosome 17, and that this is accompanied by duplication of the neighboring genomic region spanning 323 kb. However, none of the genes in this region were abrogated. These results suggest that the severe immunodeficiency seen in tgε26 mice is not due to gene disruption resulting from transgenic integration. | |||||||||||||||||||||
| 書誌情報 |
en : PLOS ONE 巻 5, 号 12, p. e14391, 発行日 2010-12-22 |
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| 収録物ID | ||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | PLOS | |||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||
| EID | ||||||||||||||||||||||
| 識別子 | 224001 | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
