| Item type |
文献 / Documents(1) |
| 公開日 |
2024-11-06 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.15252/embr.202357300 |
|
|
言語 |
ja |
|
|
関連名称 |
10.15252/embr.202357300 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging |
|
言語 |
en |
| 著者 |
Ogura, Monami
Kaminishi, Tatsuya
Shima, Takayuki
Torigata, Miku
Bekku, Nao
Tabata, Keisuke
Minami, Satoshi
Nishino, Kohei
Nezu, Akiko
Hamasaki, Maho
小迫, 英尊
Yoshimori, Tamotsu
Nakamura, Shuhei
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Lysosomes are degradative organelles and signaling hubs that maintain cell and tissue homeostasis, and lysosomal dysfunction is implicated in aging and reduced longevity. Lysosomes are frequently damaged, but their repair mechanisms remain unclear. Here, we demonstrate that damaged lysosomal membranes are repaired by microautophagy (a process termed “microlysophagy”) and identify key regulators of the first and last steps. We reveal the AGC kinase STK38 as a novel microlysophagy regulator. Through phosphorylation of the scaffold protein DOK1, STK38 is specifically required for the lysosomal recruitment of the AAA+ ATPase VPS4, which terminates microlysophagy by promoting the disassembly of ESCRT components. By contrast, microlysophagy initiation involves non‐canonical lipidation of ATG8s, especially the GABARAP subfamily, which is required for ESCRT assembly through interaction with ALIX. Depletion of STK38 and GABARAPs accelerates DNA damage‐induced cellular senescence in human cells and curtails lifespan in C. elegans, respectively. Thus, microlysophagy is regulated by STK38 and GABARAPs and could be essential for maintaining lysosomal integrity and preventing aging. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ESCRT |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lysosome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
microautophagy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
non-canonical ATG8 lipidation |
| 書誌情報 |
en : EMBO Reports
巻 24,
号 12,
p. e57300,
発行日 2023-11-21
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
14693178 |
| 出版者 |
|
|
出版者 |
EMBO Press |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
409531 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
embr_24_12_e57300.pdf (18 MB)
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