| Item type |
文献 / Documents(1) |
| 公開日 |
2025-03-21 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.isci.2024.109107 |
|
|
関連名称 |
10.1016/j.isci.2024.109107 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism |
| 著者 |
Yi, Binbin
Tanaka, Yuri L.
Cornish, Daphne
小迫, 英尊
Butlertanaka, Erika P.
Sengupta, Prabuddha
Lippincott-Schwartz, Jennifer
Hultquist, Judd F.
Saito, Akatsuki
Yoshimura, Shige H.
|
| 抄録 |
|
|
内容記述 |
Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system. Several host restriction factors that inhibit human immunodeficiency virus type 1 (HIV-1) have been identified, but most of them are antagonized by viral proteins. Here, we describe CCHC-type zinc-finger-containing protein 3 (ZCCHC3) as a novel HIV-1 restriction factor that suppresses the production of HIV-1 and other retroviruses, but does not appear to be directly antagonized by viral proteins. It acts by binding to Gag nucleocapsid (GagNC) via zinc-finger motifs, which inhibits viral genome recruitment and results in genome-deficient virion production. ZCCHC3 also binds to the long terminal repeat on the viral genome via the middle-folded domain, sequestering the viral genome to P-bodies, which leads to decreased viral replication and production. This distinct, dual-acting antiviral mechanism makes upregulation of ZCCHC3 a novel potential therapeutic strategy. |
| 書誌情報 |
en : iScience
巻 27,
号 3,
p. 109107,
発行日 2024-02-05
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
25890042 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
409525 |
| 言語 |
|
|
言語 |
eng |
isci_27_3_109107.pdf (6.5 MB)
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