| Item type |
文献 / Documents(1) |
| 公開日 |
2025-03-03 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.isci.2022.105766 |
|
|
関連名称 |
10.1016/j.isci.2022.105766 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality |
| 著者 |
Kobayashi, Hiroaki
Takemoto, Kenji
Sanbo, Makoto
Hirabayashi, Masumi
Hirabayashi, Takahiro
平山, 晃斉
Kiyonari, Hiroshi
Abe, Takaya
Yagi, Takeshi
|
| 抄録 |
|
|
内容記述 |
Clustered protocadherin is a family of cell-surface recognition molecules implicated in neuronal connectivity that has a diverse isoform repertoire and homophilic binding specificity. Mice have 58 isoforms, encoded by Pcdhα, β, and γ gene clusters, and mutant mice lacking all isoforms died after birth, displaying massive neuronal apoptosis and synapse loss. The current hypothesis is that the three specific γC-type isoforms, especially γC4, are essential for the phenotype, raising the question about the necessity of isoform diversity. We generated TC mutant mice that expressed the three γC-type isoforms but lacked all the other 55 isoforms. The TC mutants died immediately after birth, showing massive neuronal death, and γC3 or γC4 expression did not prevent apoptosis. Restoring the α- and β-clusters with the three γC alleles rescued the phenotype, suggesting that along with the three γC-type isoforms, other isoforms are also required for the survival of neurons and individual mice. |
| 書誌情報 |
en : iScience
巻 26,
号 1,
p. 105766,
発行日 2023-01-20
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
25890042 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
406750 |
| 言語 |
|
|
言語 |
eng |
isci_26_1_105766.pdf (6.7 MB)
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