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Role of TNF Ligand and Receptor Family in the Lymphoid Organogenesis Defined by Gene Targeting
https://tokushima-u.repo.nii.ac.jp/records/2000955
https://tokushima-u.repo.nii.ac.jp/records/2000955b50677af-5022-4ec1-91e1-9bf68f4f612b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
LID201111172003.pdf (164 KB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2011-11-22 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Role of TNF Ligand and Receptor Family in the Lymphoid Organogenesis Defined by Gene Targeting | |||||||||||
| 言語 | en | |||||||||||
| 著者 |
松本, 満
× 松本, 満
WEKO
1118
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | The molecular basis of lymphoid organogenesis has recently been elucidated using gene-targeted mice. Mice deficient in lymphotoxin-α (LTα) lack lymph nodes and Peyer's patches. The action of LTα in lymphoid organogenesis is mediated mostly by the membrane form of LT by a mechanism independent of TNF receptor I (TNFR-I) or II (TNFR-II). Additionally, follicular dendritic cell (FDC) clusters or germinal centers fail to develop in the spleen of LTα-deficient mice. Mice deficient in either TNFR-I or LTβR also fail to develop splenic FDC clusters and germinal centers, indicating that signaling through both TNFR-I and LTβR is required for the development of these structures. The mechanisms underlying the defective lymphoid organogenesis in LTα-deficient mice, together with a natural mutant strain, alymphoplasia (aly) mice, which manifest a quite similar phenotype to LTα-deficient mice, were investigated by generating aggregation chimeras. These studies demonstrate that LTα and the aly gene product together control lymphoid organogenesis with a close mechanistic relationship in their biochemical pathways through governing distinct cellular compartments;the former acting as a circulating ligand and the latter as a LTβR-signaling molecule expressed by the stroma of the lymphoid organs. | |||||||||||
| 言語 | en | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | lymphotoxin | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | TNF | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | lymph node | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | spleen | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | knockout mice | |||||||||||
| 書誌情報 |
en : The journal of medical investigation : JMI 巻 46, 号 3-4, p. 141-150, 発行日 1999 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 13431420 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA11166929 | |||||||||||
| 備考 | ||||||||||||
| 言語 | ja | |||||||||||
| 値 | データ元 : http://medical.med.tokushima-u.ac.jp/jmi/ | |||||||||||
| EID | ||||||||||||
| 識別子 | 72145 | |||||||||||
| 識別子タイプ | URI | |||||||||||
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| 言語 | eng | |||||||||||
