| Item type |
文献 / Documents(1) |
| 公開日 |
2011-11-22 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Possible role of bradykinin on stimulus-secretion coupling in adrenal chromaffin cells |
|
言語 |
en |
| 著者 |
ホウチ, ヒトシ
東, 満美
吉栖, 正典
玉置, 俊晃
水口, 和生
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Nonapeptide bradykinin is known to be a central nervous system neurotrans-mitter and to play a role in regulation of neuronal function. However, few details are known of the function of its peptide on stimulus-secretion coupling in neuronal cells. In this article, the role of bradykinin on catecholamine biosynthesis, secretion and Ca2+movement in adrenal chromaffin cells as a model for catecholamine-containing neurons are examined. Bradykinin receptors are classified as B1 and B2 receptor subtypes. These receptors are present on the adrenal chromaffin cell membrane. Bradykinin increases the influx of Ca2+ and the turnover of phosphoinositide through the stimulation of bradykinin B2 receptor. The secretion of catecholamine from the cells is initiated by the raise of [Ca2+]i. An increase in [Ca2+]i and production of diacylglycerol stimulate the activation of calcium-dependent protein kinases. These kinases stimulate the activation of tyrosine hydroxylase, a rate-limiting enzyme in the biosynthesis of catecholamine. Otherwise, bradykinin increases Ca2+ efflux from the cells through the stimulation of the bradykinin-B2 receptor. This action may be explained by an extracellular Na+-dependent mechanism, probably through acceleration of Na+/Ca2+ exchange. It is interesting that bradykinin, which stimulates the biosynthesis and secretion of catecholamine in adrenal chromaffin cells, plays a role in the termination of calcium-signal transduction through the stimu-lation of Ca2+ efflux from the cells. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Bradykinin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Catecholamine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Biosynthesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Secretion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Calcium |
| 書誌情報 |
en : The journal of medical investigation : JMI
巻 46,
号 1-2,
p. 1-9,
発行日 1999
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 備考 |
|
|
言語 |
ja |
|
値 |
データ元 : http://medical.med.tokushima-u.ac.jp/jmi/ |
| EID |
|
|
識別子 |
131141 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
LID201111162001.pdf (426 KB)
