WEKO3
アイテム
睡眠と生体リズム
https://tokushima-u.repo.nii.ac.jp/records/2001053
https://tokushima-u.repo.nii.ac.jp/records/2001053c0fcbe44-fa23-4f2f-a94b-75e3b7058ec8
| 名前 / ファイル | ライセンス | アクション |
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LID201208292006.pdf (140 KB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2012-08-29 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 睡眠と生体リズム | |||||||||||
| タイトル | ||||||||||||
| タイトル | スイミン ト セイタイ リズム | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | Sleep and Biological Clock | |||||||||||
| 著者 |
勢井, 宏義
× 勢井, 宏義
WEKO
1549
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| 抄録 | ||||||||||||
| 内容記述 | Circadian rhythm is an endogenous rhythm controlled by a master oscillator (biological clock) in the supra-chiasmatic nucleus (SCN), affecting on the almost all physiological functions including sleep/wake regulation. Recently the biological clock has been shown to function at the molecular level, and several circadian-related genes have been identified, such as the Clock, Per 1-3, Bmal 1 or Cry 1, 2. We observed the sleep/wake rhythm in cry 1, 2 double knockout mice and clock mutant mice. Both strains have lost the circadian oscillation in the expression of circadian-related genes. Cry 1, 2 double knockout mice show the entrained sleep/wake rhythm to ordinary light-dark (LD) cycle, although they show completely flattened rhythm under the constant dark (DD) condition. On the other hand, clock mutant mice show the persistent circadian sleep/wake rhythm under even DD conditions. Although the expression of circadian-related genes do not oscillate, the clock mutant mice have potent circadian rhythm in body core temperature, behavior, sleep/wake and cortisol etc. The clock mutant mice have a longer (27 hrs) period of free-running rhythm under DD condition, and the phase of sleep/wake rhythm is delayed for about two hours comparing to the wild-type under LD condition. The important role of the circadian-related genes in the sleep/wake regulation has been indicated. The functional impairment of the circadian-related genes may be involved in the sleep disorders, such as insomnia or hypersomnia. |
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| キーワード | ||||||||||||
| 主題 | circadian | |||||||||||
| キーワード | ||||||||||||
| 主題 | sleep | |||||||||||
| キーワード | ||||||||||||
| 主題 | circadian-related genes | |||||||||||
| 書誌情報 |
ja : 四国医学雑誌 巻 60, 号 1-2, p. 8-13, 発行日 2004-05-25 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 00373699 | |||||||||||
| 収録物ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AN00102041 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 徳島医学会 | |||||||||||
| 備考 | ||||||||||||
| 値 | 四国医学雑誌 : http://www.tokushima-u.ac.jp/med/research/shikoku_acta_medica.html | |||||||||||
| EID | ||||||||||||
| 識別子 | 136559 | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
